Projects per year
Abstract
Regulatory elements (enhancers) that are remote from promoters play a critical role in the spatial, temporal, and physiological control of gene expression. Studies on specific loci, together with genome-wide approaches, suggest that there may be many common mechanisms involved in enhancer-promoter communication. Here, we discuss the multiprotein complexes that are recruited to enhancers and the hierarchy of events taking place between regulatory elements and promoters.
| Original language | English |
|---|---|
| Pages (from-to) | 696-708 |
| Journal | Trends in Genetics |
| Volume | 31 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 12 Dec 2015 |
Fingerprint
Dive into the research topics of 'The Hierarchy of Transcriptional Activation: From Enhancer to Promoter'. Together they form a unique fingerprint.Projects
- 3 Finished
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CROATIA PROGRAMME
Wright, A. (Principal Investigator), Adams, I. (Co-investigator), Aligianis, I. (Co-investigator), Baldock, R. (Co-investigator), Bickmore, W. (Co-investigator), Caceres, J. (Co-investigator), Dorin, J. (Co-investigator), Dunlop, M. (Co-investigator), FitzPatrick, D. (Co-investigator), Haley, C. (Co-investigator), Hastie, N. (Co-investigator), Hill, B. (Co-investigator), Jackson, I. (Co-investigator), Jackson, A. (Co-investigator), Kudla, G. (Co-investigator), Meehan, R. (Co-investigator), O'Connell, M. (Co-investigator), Overton, I. (Co-investigator), Patton, E. (Co-investigator), Taylor, M. (Co-investigator), Tenesa, A. (Co-investigator) & Van Heyningen, V. (Co-investigator)
1/04/12 → 31/07/13
Project: Research
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The role of spatial nuclear organisation in genome function
Bickmore, W. (Principal Investigator)
1/04/12 → 31/03/18
Project: Research
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FunctionalEdge: Determining the roles of the nuclear peri
Bickmore, W. (Principal Investigator)
1/10/11 → 28/02/16
Project: Research
Research output
- 1 Web publication/site
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The hierarchy of transcriptional activation: from enhancer to promoter
Vernimmen, D. & Bickmore, W., 2 Feb 2016Research output: Non-textual form › Web publication/site
Open Access