The Hippo Pathway in Prostate Cancer

Omar Salem, Carsten Hansen

Research output: Contribution to journalArticlepeer-review

Abstract

Despite recent efforts, prostate cancer (PCa) remains one of the most common cancers in men. Currently, there is no effective treatment for castration-resistant prostate cancer (CRPC). There is, therefore, an urgent need to identify new therapeutic targets. The Hippo pathway and its downstream effectors—the transcriptional co-activators, Yes-associated protein (YAP) and its paralog, transcriptional co-activator with PDZ-binding motif (TAZ)—are foremost regulators of stem cells and cancer biology. Defective Hippo pathway signaling and YAP/TAZ hyperactivation are common across various cancers. Here, we draw on insights learned from other types of cancers and review the latest advances linking the Hippo pathway and YAP/TAZ to PCa onset and progression. We examine the regulatory interaction between Hippo-YAP/TAZ and the androgen receptor (AR), as main regulators of PCa development, and how uncontrolled expression of YAP/TAZ drives castration resistance by inducing cellular stemness. Finally, we survey the potential therapeutic targeting of the Hippo pathway and YAP/TAZ to overcome PCa. View Full-Text
Keywords: hippo pathway; YAP/TAZ; prostate cancer; castration resistance; signal cross-talk; feedback loops
Original languageEnglish
Pages (from-to)370
JournalCells
Volume8
Issue number4
DOIs
Publication statusPublished - 23 Apr 2019

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