The hippocampus and delayed recall: Bigger is not necessarily better?

JK Foster*, A Meikle, G Goodson, AR Mayes, M Howard, SI Sunram, E Cezayirli, N Roberts

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Healthy young female participants were tested on a measure of delayed verbal recall and then received volumetric Magnetic Resonance Imaging (MRI) scans. The analysis of the MRI scans focused on the volume of the hippocampus. Left hippocampal volume was negatively associated with the level of delayed verbal recall performance. This relationship was confirmed in further testing. This finding is consistent with a previous report of a similar relationship in healthy elderly individuals, but not in patients with Alzheimer's disease, in whom the opposite relationship was observed. An explanation of these findings in terms of impaired neural pruning of the hippocampus is advanced, whereby insufficient pruning of the hippocampus during childhood and adolescence (following adequate growth) may lead to reduced mnemonic efficiency.

Original languageEnglish
Pages (from-to)715-732
Number of pages18
JournalMemory
Volume7
Issue number5-6
Publication statusPublished - 1999

Keywords / Materials (for Non-textual outputs)

  • POSITRON EMISSION TOMOGRAPHY
  • MEDIAL TEMPORAL-LOBE
  • ALZHEIMERS-DISEASE
  • RECOGNITION MEMORY
  • PARAHIPPOCAMPAL-GYRUS
  • EPISODIC MEMORY
  • MR VOLUMETRY
  • ATROPHY
  • RETRIEVAL
  • FRAMEWORK

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