The human homolog of the mouse brown gene maps to the short arm of chromosome 9 and extends the known region of homology with mouse chromosome 4

C Abbott, I J Jackson, B Carritt, S Povey

Research output: Contribution to journalArticlepeer-review

Abstract

The mouse brown locus encodes a tyrosinase-related protein, TRP-1. The human homolog of TRP-1 was recently cloned from a melanoma cDNA library and sequenced. We have made oligonucleotide primers corresponding to the human TRP1 3' untranslated region and used them to map the human TRP1 gene by species-specific PCR in human/rodent somatic cell hybrids. By this means, the human TRP1 gene has been mapped to the short arm of chromosome 9.
Original languageEnglish
Pages (from-to)471-3
Number of pages3
JournalGenomics
Volume11
Issue number2
Publication statusPublished - 1991

Keywords

  • Animals
  • Bacterial Proteins
  • Base Sequence
  • Chromosome Mapping
  • Chromosomes, Human, Pair 9
  • DNA-Binding Proteins
  • Gene Library
  • Humans
  • Hybrid Cells
  • Melanoma
  • Mice
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Trans-Activators

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