The immunology of sepsis

Tom van der Poll, Manu Shankar-Hari, W. Joost Wiersinga

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to an infection. This recently implemented definition does not capture the heterogeneity or the underlying pathophysiology of the syndrome, which is characterized by concurrent unbalanced hyperinflammation and immune suppression. Here, we review current knowledge of aberrant immune responses during sepsis and recent initiatives to stratify patients with sepsis into subgroups that are more alike from a clinical and/or pathobiological perspective, which could be key for identification of patients who are more likely to benefit from specific immune interventions.
Original languageUndefined/Unknown
Pages (from-to)2450-2464
Number of pages15
JournalImmunity
Volume54
Issue number11
DOIs
Publication statusPublished - 9 Nov 2021

Cite this