Abstract / Description of output
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to an infection. This recently implemented definition does not capture the heterogeneity or the underlying pathophysiology of the syndrome, which is characterized by concurrent unbalanced hyperinflammation and immune suppression. Here, we review current knowledge of aberrant immune responses during sepsis and recent initiatives to stratify patients with sepsis into subgroups that are more alike from a clinical and/or pathobiological perspective, which could be key for identification of patients who are more likely to benefit from specific immune interventions.
Original language | Undefined/Unknown |
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Pages (from-to) | 2450-2464 |
Number of pages | 15 |
Journal | Immunity |
Volume | 54 |
Issue number | 11 |
DOIs | |
Publication status | Published - 9 Nov 2021 |