Abstract / Description of output
Aims
To describe the relationship between race/ethnicity and adverse outcomes related to coronavirus disease 2019 (COVID-19) in adults with type 2 diabetes admitted to hospital in the UK, France and USA.
Methods
Study data from the UK ABCD nationwide COVID-19 audit, the French CORONADO nationwide initiative and the USA AMERICADO multi-centre study were analysed to assess the association between race/ethnicity and severe COVID-19. Severe COVID-19 was defined as death in hospital and/or admission to the intensive care unit (ICU). Logistic regression models were used to generate age-adjusted odds-ratios.
Results
Data from 3471 patients in the ABCD audit, 2451 CORONADO patients and 9321 AMERICADO patients admitted with COVID-19 and type 2 diabetes were analysed. Race/ethnicity data were available for 3410 (98%), 2173 (89%) and 8893 (95%) patients respectively. In the UK ABCD audit cohort, Asian and Black race/ethnicity were associated with an increased risk of death/ICU admission compared to White when adjusted for age and sex (OR 2.14; 1.38-3.29 and OR 2.09; 1.17-3.74 respectively). When adjusted for additional confounders the association was stronger (Asian OR 2.88; 1.72-4.82 and Black OR 2.20; 1.12-4.30). In the CORONADO cohort Middle Eastern/North African race/ethnicity was protective against death/ICU admission (OR 0.57; 0.36-0.91). There was no association between ethnicity and death alone in the AMERICADO dataset.
Conclusion
In those with Type 2 diabetes admitted to hospital with COVID-19, a non-white race/ethnicity was associated with higher risk of death/ICU admission in the UK ABCD but not in French CORONADO or USA AMERICADO datasets. Further research is required to further our understanding of the observed discrepancies in outcomes.
To describe the relationship between race/ethnicity and adverse outcomes related to coronavirus disease 2019 (COVID-19) in adults with type 2 diabetes admitted to hospital in the UK, France and USA.
Methods
Study data from the UK ABCD nationwide COVID-19 audit, the French CORONADO nationwide initiative and the USA AMERICADO multi-centre study were analysed to assess the association between race/ethnicity and severe COVID-19. Severe COVID-19 was defined as death in hospital and/or admission to the intensive care unit (ICU). Logistic regression models were used to generate age-adjusted odds-ratios.
Results
Data from 3471 patients in the ABCD audit, 2451 CORONADO patients and 9321 AMERICADO patients admitted with COVID-19 and type 2 diabetes were analysed. Race/ethnicity data were available for 3410 (98%), 2173 (89%) and 8893 (95%) patients respectively. In the UK ABCD audit cohort, Asian and Black race/ethnicity were associated with an increased risk of death/ICU admission compared to White when adjusted for age and sex (OR 2.14; 1.38-3.29 and OR 2.09; 1.17-3.74 respectively). When adjusted for additional confounders the association was stronger (Asian OR 2.88; 1.72-4.82 and Black OR 2.20; 1.12-4.30). In the CORONADO cohort Middle Eastern/North African race/ethnicity was protective against death/ICU admission (OR 0.57; 0.36-0.91). There was no association between ethnicity and death alone in the AMERICADO dataset.
Conclusion
In those with Type 2 diabetes admitted to hospital with COVID-19, a non-white race/ethnicity was associated with higher risk of death/ICU admission in the UK ABCD but not in French CORONADO or USA AMERICADO datasets. Further research is required to further our understanding of the observed discrepancies in outcomes.
| Original language | English |
|---|---|
| Journal | The British Journal of Diabetes |
| Volume | 23 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 28 Jun 2023 |