The Impact of Tumour pH on Cancer Progression; Strategies for Clinical Intervention

Carol Ward; James Meehan; Mark E Gray; Alan F Murray; David Argyle; Ian Kunkler; Simon Langdon

doi:10.37349/etat.2020.00005

The Impact of Tumour pH on Cancer Progression; Strategies for Clinical Intervention

Carol Ward, James Meehan, Mark E Gray, Alan F Murray, David Argyle, Ian Kunkler, Simon Langdon

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Dysregulation of cellular pH is frequent in solid tumours and provides potential opportunities for therapeutic intervention. The acidic microenvironment within a tumour can promote migration, invasion and metastasis of cancer cells through a variety of mechanisms. Pathways associated with the control of intracellular pH that are under consideration for intervention include carbonic anhydrase IX (CAIX), the monocarboxylate transporters (MCT1 and MCT4), the vacuolar-type H+-ATPase proton pump (V-ATPase), and the sodium-hydrogen exchanger 1 (NHE1). This review will describe progress in the development of inhibitors to these targets.

Original language	English
Journal	Exploration of Targeted Anti-tumour Therapy
Early online date	9 Apr 2020
DOIs	https://doi.org/10.37349/etat.2020.00005
Publication status	E-pub ahead of print - 9 Apr 2020

Keywords / Materials (for Non-textual outputs)

Tumour pH
Acidosis
Inhibitor
Hypoxia
CAIX
NHE1
MCT1
MCT4
V-ATPase

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10.37349/etat.2020.00005

The impact of tumour pH on cancer progression _ strategies for clinical interventionFinal published version, 733 KB

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title = "The Impact of Tumour pH on Cancer Progression; Strategies for Clinical Intervention",

abstract = "Dysregulation of cellular pH is frequent in solid tumours and provides potential opportunities for therapeutic intervention. The acidic microenvironment within a tumour can promote migration, invasion and metastasis of cancer cells through a variety of mechanisms. Pathways associated with the control of intracellular pH that are under consideration for intervention include carbonic anhydrase IX (CAIX), the monocarboxylate transporters (MCT1 and MCT4), the vacuolar-type H+-ATPase proton pump (V-ATPase), and the sodium-hydrogen exchanger 1 (NHE1). This review will describe progress in the development of inhibitors to these targets.",

keywords = "Tumour pH, Acidosis, Inhibitor, Hypoxia, CAIX, NHE1, MCT1, MCT4, V-ATPase",

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year = "2020",

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doi = "10.37349/etat.2020.00005",

language = "English",

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AU - Ward, Carol

AU - Meehan, James

AU - Gray, Mark E

AU - Murray, Alan F

AU - Argyle, David

AU - Kunkler, Ian

AU - Langdon, Simon

PY - 2020/4/9

Y1 - 2020/4/9

N2 - Dysregulation of cellular pH is frequent in solid tumours and provides potential opportunities for therapeutic intervention. The acidic microenvironment within a tumour can promote migration, invasion and metastasis of cancer cells through a variety of mechanisms. Pathways associated with the control of intracellular pH that are under consideration for intervention include carbonic anhydrase IX (CAIX), the monocarboxylate transporters (MCT1 and MCT4), the vacuolar-type H+-ATPase proton pump (V-ATPase), and the sodium-hydrogen exchanger 1 (NHE1). This review will describe progress in the development of inhibitors to these targets.

AB - Dysregulation of cellular pH is frequent in solid tumours and provides potential opportunities for therapeutic intervention. The acidic microenvironment within a tumour can promote migration, invasion and metastasis of cancer cells through a variety of mechanisms. Pathways associated with the control of intracellular pH that are under consideration for intervention include carbonic anhydrase IX (CAIX), the monocarboxylate transporters (MCT1 and MCT4), the vacuolar-type H+-ATPase proton pump (V-ATPase), and the sodium-hydrogen exchanger 1 (NHE1). This review will describe progress in the development of inhibitors to these targets.

KW - Tumour pH

KW - Acidosis

KW - Inhibitor

KW - Hypoxia

KW - CAIX

KW - NHE1

KW - MCT1

KW - MCT4

KW - V-ATPase

U2 - 10.37349/etat.2020.00005

DO - 10.37349/etat.2020.00005

M3 - Article

JO - Exploration of Targeted Anti-tumour Therapy

JF - Exploration of Targeted Anti-tumour Therapy

ER -

The Impact of Tumour pH on Cancer Progression; Strategies for Clinical Intervention

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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