The Impact of Tumour pH on Cancer Progression; Strategies for Clinical Intervention

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Abstract

Dysregulation of cellular pH is frequent in solid tumours and provides potential opportunities for therapeutic intervention. The acidic microenvironment within a tumour can promote migration, invasion and metastasis of cancer cells through a variety of mechanisms. Pathways associated with the control of intracellular pH that are under consideration for intervention include carbonic anhydrase IX (CAIX), the monocarboxylate transporters (MCT1 and MCT4), the vacuolar-type H+-ATPase proton pump (V-ATPase), and the sodium-hydrogen exchanger 1 (NHE1). This review will describe progress in the development of inhibitors to these targets.
Original languageEnglish
JournalExploration of Targeted Anti-tumour Therapy
Early online date9 Apr 2020
DOIs
Publication statusE-pub ahead of print - 9 Apr 2020

Keywords

  • Tumour pH
  • Acidosis
  • Inhibitor
  • Hypoxia
  • CAIX
  • NHE1
  • MCT1
  • MCT4
  • V-ATPase

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