The importance of microvascular inflammation in ageing and age-related diseases: a position paper from the ESH working group on small arteries, section of microvascular inflammation

Alessandro Mengozzi, Carolina de Ciuceis, Raffaella Dell'oro, Georgios Georgiopoulos, Antonios Lazaridis, Ryszard Nosalski, George Pavlidis, Simon Tual-Chalot, Claudia Agabiti-Rosei, Panagiota Anyfanti, Livia L Camargo, Edyta Dąbrowska, Fosca Quarti-Trevano, Marcin Hellmann, Stefano Masi, Georgios Mavraganis, Augusto C Montezano, Francesco J Rios, Pawel J Winklewski, Jacek WolfSarah Costantino, Eugenia Gkaliagkousi, Guido Grassi, Tomasz J Guzik, Ignatios Ikonomidis, Krzysztof Narkiewicz, Francesco Paneni, Damiano Rizzoni, Kimon Stamatelopoulos, Konstantinos Stellos, Stefano Taddei, Rhian M Touyz, Areti Triantafyllou, Agostino Virdis

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Microcirculation is pervasive and orchestrates a profound regulatory cross-talk with the surrounding tissue and organs. Similarly, it is one of the earliest biological systems targeted by environmental stressors and consequently involved in the development and progression of ageing and age-related disease. Microvascular dysfunction, if not targeted, leads to a steady derangement of the phenotype, which cumulates comorbidities and eventually results in a nonrescuable, very high-cardiovascular risk. Along the broad spectrum of pathologies, both shared and distinct molecular pathways and pathophysiological alteration are involved in the disruption of microvascular homeostasis, all pointing to microvascular inflammation as the putative primary culprit. This position paper explores the presence and the detrimental contribution of microvascular inflammation across the whole spectrum of chronic age-related diseases, which characterise the 21st-century healthcare landscape. The manuscript aims to strongly affirm the centrality of microvascular inflammation by recapitulating the current evidence and providing a clear synoptic view of the whole cardiometabolic derangement. Indeed, there is an urgent need for further mechanistic exploration to identify clear, very early or disease-specific molecular targets to provide an effective therapeutic strategy against the otherwise unstoppable rising prevalence of age-related diseases.

Original languageEnglish
JournalJournal of Hypertension
Early online date27 Jun 2023
DOIs
Publication statusE-pub ahead of print - 27 Jun 2023

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