The importance of the SIBLING family of proteins on skeletal mineralisation and bone remodelling

Research output: Contribution to journalLiterature reviewpeer-review


The small integrin-binding ligand N-linked glycoprotein (SIBLING) family consists of osteopontin, bone sialoprotein, dentin matrix protein 1, dentin sialophosphoprotein and matrix extracellular phosphoglycoprotein. These proteins share many structural characteristics and are primarily located in bone and dentin. Accumulating evidence has implicated the SIBLING proteins in matrix mineralisation. Therefore, in this review, we discuss the individual role that each of the SIBLING proteins has in this highly orchestrated process. In particular, we emphasise how the nature and extent of their proteolytic processing and post-translational modification affect their functional role. Finally, we describe the likely roles of the SIBLING proteins in clinical disorders of hypophosphataemia and their potential therapeutic use. Journal of Endocrinology (2012) 214, 241-255

Original languageEnglish
Pages (from-to)241-255
Number of pages15
JournalJournal of Endocrinology
Issue number3
Early online date16 Jun 2012
Publication statusPublished - Sep 2012

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