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Abstract / Description of output
According to the theory of neuronal health, neurons exist in a spectrum of states ranging from highly resilient to vulnerable. An unhealthy neuron may be rendered dysfunctional or non-viable by an insult that would ordinarily be non-toxic to a healthy neuron. Over the years it has become clear that a neuron's health is subject to dynamic regulation by electrical or synaptic activity. This review highlights recently identified activity dependent signalling events that boost neuronal health through the transcriptional control of pro-apoptotic and anti-apoptotic genes, the enhancement of antioxidant defences, and the regulation of mitochondrial and neurotrophic factor availability. Furthermore, activity dependent signals have recently been shown to influence a variety of events specific to individual neurodegenerative diseases, which will also be highlighted.
Original language | English |
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Pages (from-to) | 299-305 |
Number of pages | 7 |
Journal | Current Opinion in Neurobiology |
Volume | 21 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2011 |
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Dive into the research topics of 'The influence of synaptic activity on neuronal health'. Together they form a unique fingerprint.Projects
- 1 Finished
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FELLOWSHIP: Control of neuroprotection through NMDA receptor dependant regulation of antioxidant status.
1/10/10 → 30/11/17
Project: Research