The influence of the menstrual cycle, normal pregnancy and pre-eclampsia on platelet activation

A O Robb, J N Din, N L Mills, I B J Smith, A Blomberg, M N L Zikry, Jennifer Raftis, D E Newby, F C Denison

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Platelet activation has a key role in mediating thrombotic and inflammatory events. This study aimed to determine the influence of the menstrual cycle, pregnancy and pre-eclampsia on in vivo platelet activation. Twelve healthy nulliparous, non-smoking women with regular menses were studied over a single menstrual cycle. Twenty-one healthy primigravida pregnant women were studied longitudinally at 16, 24, 32 and 37 weeks gestation and seven weeks post-partum. Sixteen primigravida women with pre-eclampsia were studied at time of diagnosis and at seven weeks post-partum. Platelet-monocyte aggregates and platelet-surface P-selectin expression were assessed by flow-cytometry. Soluble P-selectin and CD40 ligand (CD40L) were measured by ELISA. Markers of platelet activation did not vary over the menstrual cycle. Platelet-monocyte aggregates were greater in the third trimester of pregnancy compared to non-pregnant women (p=0.003). Platelet surface and plasma soluble P-selectin concentrations increased with gestation (p
Original languageEnglish
Pages (from-to)372-8
Number of pages7
JournalThrombosis and Haemostasis
Volume103
Issue number2
DOIs
Publication statusPublished - 2010

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