The interaction of bacterial pathogens with platelets

J Ross Fitzgerald, Timothy J Foster, Dermot Cox

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

In recent years, the frequency of serious cardiovascular infections such as endocarditis has increased, particularly in association with nosocomially acquired antibiotic-resistant pathogens. Growing evidence suggests a crucial role for the interaction of bacteria with human platelets in the pathogenesis of cardiovascular infections. Here, we review the nature of the interactions between platelets and bacteria, and the role of these interactions in the pathogenesis of endocarditis and other cardiovascular diseases.
Original languageEnglish
Pages (from-to)445-57
Number of pages13
JournalNature Reviews Microbiology
Issue number6
Publication statusPublished - Jun 2006

Keywords / Materials (for Non-textual outputs)

  • Animals
  • Blood Platelets
  • Borrelia burgdorferi
  • Cardiovascular Diseases
  • Cross Infection
  • Endocarditis, Bacterial
  • Helicobacter pylori
  • Humans
  • Platelet Activation
  • Porphyromonas gingivalis
  • Staphylococcus aureus
  • Streptococcus


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