The interaction of bacterial pathogens with platelets

J Ross Fitzgerald; Timothy J Foster; Dermot Cox

doi:10.1038/nrmicro1425

The interaction of bacterial pathogens with platelets

J Ross Fitzgerald, Timothy J Foster, Dermot Cox

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

In recent years, the frequency of serious cardiovascular infections such as endocarditis has increased, particularly in association with nosocomially acquired antibiotic-resistant pathogens. Growing evidence suggests a crucial role for the interaction of bacteria with human platelets in the pathogenesis of cardiovascular infections. Here, we review the nature of the interactions between platelets and bacteria, and the role of these interactions in the pathogenesis of endocarditis and other cardiovascular diseases.

Original language	English
Pages (from-to)	445-57
Number of pages	13
Journal	Nature Reviews Microbiology
Volume	4
Issue number	6
DOIs	https://doi.org/10.1038/nrmicro1425
Publication status	Published - Jun 2006

Keywords

Animals
Blood Platelets
Borrelia burgdorferi
Cardiovascular Diseases
Cross Infection
Endocarditis, Bacterial
Helicobacter pylori
Humans
Platelet Activation
Porphyromonas gingivalis
Staphylococcus aureus
Streptococcus

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10.1038/nrmicro1425

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title = "The interaction of bacterial pathogens with platelets",

abstract = "In recent years, the frequency of serious cardiovascular infections such as endocarditis has increased, particularly in association with nosocomially acquired antibiotic-resistant pathogens. Growing evidence suggests a crucial role for the interaction of bacteria with human platelets in the pathogenesis of cardiovascular infections. Here, we review the nature of the interactions between platelets and bacteria, and the role of these interactions in the pathogenesis of endocarditis and other cardiovascular diseases.",

keywords = "Animals, Blood Platelets, Borrelia burgdorferi, Cardiovascular Diseases, Cross Infection, Endocarditis, Bacterial, Helicobacter pylori, Humans, Platelet Activation, Porphyromonas gingivalis, Staphylococcus aureus, Streptococcus",

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KW - Borrelia burgdorferi

KW - Cardiovascular Diseases

KW - Cross Infection

KW - Endocarditis, Bacterial

KW - Helicobacter pylori

KW - Humans

KW - Platelet Activation

KW - Porphyromonas gingivalis

KW - Staphylococcus aureus

KW - Streptococcus

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The interaction of bacterial pathogens with platelets

Abstract

Keywords

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