The InterPro Database, 2003 brings increased coverage and new features

Nicola J Mulder, Rolf Apweiler, Teresa K Attwood, Amos Bairoch, Daniel Barrell, Alex Bateman, David Binns, Margaret Biswas, Paul Bradley, Peer Bork, Phillip Bucher, Richard R Copley, Emmanuel Courcelle, Ujjwal Das, Richard Durbin, Laurent Falquet, Wolfgang Fleischmann, Sam Griffiths-Jones, Daniel Haft, Nicola HarteNicolas Hulo, Daniel Kahn, Alexander Kanapin, Maria Krestyaninova, Rodrigo Lopez, Ivica Letunic, David Lonsdale, Ville Silventoinen, Sandra E Orchard, Marco Pagni, David Peyruc, Chris P Ponting, Jeremy D Selengut, Florence Servant, Christian J A Sigrist, Robert Vaughan, Evgueni M Zdobnov

Research output: Contribution to journalArticlepeer-review

Abstract

InterPro, an integrated documentation resource of protein families, domains and functional sites, was created in 1999 as a means of amalgamating the major protein signature databases into one comprehensive resource. PROSITE, Pfam, PRINTS, ProDom, SMART and TIGRFAMs have been manually integrated and curated and are available in InterPro for text- and sequence-based searching. The results are provided in a single format that rationalises the results that would be obtained by searching the member databases individually. The latest release of InterPro contains 5629 entries describing 4280 families, 1239 domains, 95 repeats and 15 post-translational modifications. Currently, the combined signatures in InterPro cover more than 74% of all proteins in SWISS-PROT and TrEMBL, an increase of nearly 15% since the inception of InterPro. New features of the database include improved searching capabilities and enhanced graphical user interfaces for visualisation of the data. The database is available via a webserver (http://www.ebi.ac.uk/interpro) and anonymous FTP (ftp://ftp.ebi.ac.uk/pub/databases/interpro).

Original languageEnglish
Pages (from-to)315-8
Number of pages4
JournalNucleic Acids Research
Volume31
Issue number1
Publication statusPublished - 1 Jan 2003

Keywords

  • Animals
  • Computer Graphics
  • Databases, Protein
  • Protein Processing, Post-Translational
  • Protein Structure, Tertiary
  • Proteins
  • Repetitive Sequences, Amino Acid
  • User-Computer Interface

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