The intracellular interactions of the L1 family of cell adhesion molecules

Lissa Herron, Maria Hill, Fleur Davey, Frank J Gunn-Moore

Research output: Contribution to journalLiterature reviewpeer-review


The L1 family of CAMs (cell adhesion molecules) has long aroused the interest of researchers, but primarily the extracellular interactions of these proteins have been elucidated. More recently, attention has turned to the intracellular signalling potentiated by transmembrane proteins and the cytoplasmic proteins with which they can interact. The present review brings up to date the current body of published knowledge for the intracellular interactions of L1-CAM family proteins and the potential importance of these interactions for the mechanisms of L1-CAM action.
Original languageEnglish
Pages (from-to)519-31
Number of pages13
JournalBiochemical Journal
Issue number3
Publication statusPublished - May 2009


  • Animals
  • Ankyrins/metabolism
  • Intracellular Space/metabolism
  • Neural Cell Adhesion Molecule L1/chemistry
  • Neural Cell Adhesion Molecule L1/metabolism
  • Protein Binding
  • Protein Interaction Mapping
  • Signal Transduction


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