The kinetochore proteins Pcs1 and Mde4 and heterochromatin are required to prevent merotelic orientation

Juraj Gregan, Christian G Riedel, Alison L Pidoux, Yuki Katou, Cornelia Rumpf, Alexander Schleiffer, Stephen E Kearsey, Katsuhiko Shirahige, Robin C Allshire, Kim Nasmyth

Research output: Contribution to journalArticlepeer-review

Abstract

Accurate chromosome segregation depends on the establishment of correct-amphitelic-kinetochore orientation. Merotelic kinetochore orientation is an error that occurs when a single kinetochore attaches to microtubules emanating from opposite spindle poles, a condition that hinders segregation of the kinetochore to a spindle pole in anaphase. To avoid chromosome missegregation resulting from merotelic kinetochore orientation, cells have developed mechanisms to prevent or correct merotelic attachment. A protein called Pcs1 has been implicated in preventing merotelic attachment in mitosis and meiosis II in the fission yeast S. pombe.
Original languageEnglish
Pages (from-to)1190-200
Number of pages11
JournalCurrent Biology
Volume17
Issue number14
DOIs
Publication statusPublished - 2007

Keywords

  • DNA
  • CELLCYCLE

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