Abstract / Description of output
Accurate chromosome segregation depends on the establishment of correct-amphitelic-kinetochore orientation. Merotelic kinetochore orientation is an error that occurs when a single kinetochore attaches to microtubules emanating from opposite spindle poles, a condition that hinders segregation of the kinetochore to a spindle pole in anaphase. To avoid chromosome missegregation resulting from merotelic kinetochore orientation, cells have developed mechanisms to prevent or correct merotelic attachment. A protein called Pcs1 has been implicated in preventing merotelic attachment in mitosis and meiosis II in the fission yeast S. pombe.
Original language | English |
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Pages (from-to) | 1190-200 |
Number of pages | 11 |
Journal | Current Biology |
Volume | 17 |
Issue number | 14 |
DOIs | |
Publication status | Published - 2007 |
Keywords / Materials (for Non-textual outputs)
- DNA
- CELLCYCLE