The long and the short of RNA maps

Jasmina Ponjavic, Chris P Ponting

Research output: Contribution to journalArticlepeer-review

Abstract

The landscapes of mammalian genomes are characterized by complex patterns of intersecting and overlapping sense and antisense transcription, giving rise to large numbers of coding and non-protein-coding RNAs (ncRNAs). A recent report by Kapranov and colleagues(1) describes three potentially novel classes of RNAs located at the very edges of protein-coding genes. The presence of RNAs from one of these classes appears to be correlated with the expression levels of their associated genes. These results suggest that a proportion of these RNAs might have roles in the cis-regulation of neighbouring protein-coding genes' expression.

Original languageEnglish
Pages (from-to)1077-80
Number of pages4
JournalBioEssays
Volume29
Issue number11
DOIs
Publication statusPublished - Nov 2007

Keywords

  • Animals
  • Dosage Compensation, Genetic
  • Evolution, Molecular
  • Gene Expression
  • Gene Silencing
  • Genome
  • Genome, Human
  • Genomic Imprinting
  • Humans
  • Mammals
  • MicroRNAs
  • Models, Genetic
  • Protein Biosynthesis
  • RNA
  • RNA, Small Interfering
  • RNA, Small Nuclear
  • RNA, Small Nucleolar
  • RNA, Untranslated
  • Sequence Analysis, RNA
  • Transcription, Genetic

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