THE LONG-TERM PROGNOSTIC-SIGNIFICANCE OF C-ERBB-2 IN PRIMARY BREAST-CANCER

J WINSTANLEY, T COOKE, GD MURRAY, A PLATTHIGGINS, WD GEORGE, S HOLT, M MYSKOV, A SPEDDING, BR BARRACLOUGH, PS RUDLAND

Research output: Contribution to journalArticlepeer-review

Abstract

The expression of the c-erbB-2 oncogene has been evaluated using an immunohistochemical technique with the 21 N polyclonal antibody in paraffin embedded tissue from 465 patients treated between the years 1975-1981 for Stage I and II breast cancer. One hundred and four (22%) patients exhibited positive staining. This was not associated with any other variables. Expression of the oncogene was associated with significantly poorer survival which was independent of other tumour variables.

Original languageEnglish
Pages (from-to)447-450
Number of pages4
JournalBritish Journal of Cancer
Volume63
Issue number3
Publication statusPublished - Mar 1991

Keywords

  • PROTO-ONCOGENE
  • NEU ONCOGENE
  • EXPRESSION
  • AMPLIFICATION
  • ONCOPROTEIN
  • CARCINOMA
  • OVEREXPRESSION
  • ASSOCIATION
  • RECEPTOR

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