THE LONG-TERM PROGNOSTIC-SIGNIFICANCE OF C-ERBB-2 IN PRIMARY BREAST-CANCER

J WINSTANLEY; T COOKE; GD MURRAY; A PLATTHIGGINS; WD GEORGE; S HOLT; M MYSKOV; A SPEDDING; BR BARRACLOUGH; PS RUDLAND

THE LONG-TERM PROGNOSTIC-SIGNIFICANCE OF C-ERBB-2 IN PRIMARY BREAST-CANCER

J WINSTANLEY, T COOKE, GD MURRAY, A PLATTHIGGINS, WD GEORGE, S HOLT, M MYSKOV, A SPEDDING, BR BARRACLOUGH, PS RUDLAND

Deanery of Molecular, Genetic and Population Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The expression of the c-erbB-2 oncogene has been evaluated using an immunohistochemical technique with the 21 N polyclonal antibody in paraffin embedded tissue from 465 patients treated between the years 1975-1981 for Stage I and II breast cancer. One hundred and four (22%) patients exhibited positive staining. This was not associated with any other variables. Expression of the oncogene was associated with significantly poorer survival which was independent of other tumour variables.

Original language	English
Pages (from-to)	447-450
Number of pages	4
Journal	British Journal of Cancer
Volume	63
Issue number	3
Publication status	Published - Mar 1991

Keywords / Materials (for Non-textual outputs)

PROTO-ONCOGENE
NEU ONCOGENE
EXPRESSION
AMPLIFICATION
ONCOPROTEIN
CARCINOMA
OVEREXPRESSION
ASSOCIATION
RECEPTOR

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title = "THE LONG-TERM PROGNOSTIC-SIGNIFICANCE OF C-ERBB-2 IN PRIMARY BREAST-CANCER",

abstract = "The expression of the c-erbB-2 oncogene has been evaluated using an immunohistochemical technique with the 21 N polyclonal antibody in paraffin embedded tissue from 465 patients treated between the years 1975-1981 for Stage I and II breast cancer. One hundred and four (22%) patients exhibited positive staining. This was not associated with any other variables. Expression of the oncogene was associated with significantly poorer survival which was independent of other tumour variables.",

keywords = "PROTO-ONCOGENE, NEU ONCOGENE, EXPRESSION, AMPLIFICATION, ONCOPROTEIN, CARCINOMA, OVEREXPRESSION, ASSOCIATION, RECEPTOR",

author = "J WINSTANLEY and T COOKE and GD MURRAY and A PLATTHIGGINS and WD GEORGE and S HOLT and M MYSKOV and A SPEDDING and BR BARRACLOUGH and PS RUDLAND",

year = "1991",

month = mar,

language = "English",

volume = "63",

pages = "447--450",

journal = "British Journal of Cancer",

issn = "0007-0920",

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T1 - THE LONG-TERM PROGNOSTIC-SIGNIFICANCE OF C-ERBB-2 IN PRIMARY BREAST-CANCER

AU - WINSTANLEY, J

AU - COOKE, T

AU - MURRAY, GD

AU - PLATTHIGGINS, A

AU - GEORGE, WD

AU - HOLT, S

AU - MYSKOV, M

AU - SPEDDING, A

AU - BARRACLOUGH, BR

AU - RUDLAND, PS

PY - 1991/3

Y1 - 1991/3

N2 - The expression of the c-erbB-2 oncogene has been evaluated using an immunohistochemical technique with the 21 N polyclonal antibody in paraffin embedded tissue from 465 patients treated between the years 1975-1981 for Stage I and II breast cancer. One hundred and four (22%) patients exhibited positive staining. This was not associated with any other variables. Expression of the oncogene was associated with significantly poorer survival which was independent of other tumour variables.

AB - The expression of the c-erbB-2 oncogene has been evaluated using an immunohistochemical technique with the 21 N polyclonal antibody in paraffin embedded tissue from 465 patients treated between the years 1975-1981 for Stage I and II breast cancer. One hundred and four (22%) patients exhibited positive staining. This was not associated with any other variables. Expression of the oncogene was associated with significantly poorer survival which was independent of other tumour variables.

KW - PROTO-ONCOGENE

KW - NEU ONCOGENE

KW - EXPRESSION

KW - AMPLIFICATION

KW - ONCOPROTEIN

KW - CARCINOMA

KW - OVEREXPRESSION

KW - ASSOCIATION

KW - RECEPTOR

M3 - Article

SN - 0007-0920

VL - 63

SP - 447

EP - 450

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 3

ER -

THE LONG-TERM PROGNOSTIC-SIGNIFICANCE OF C-ERBB-2 IN PRIMARY BREAST-CANCER

Abstract

Keywords / Materials (for Non-textual outputs)

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