The major histocompatibility complex homozygous inbred Babraham pig as a resource for veterinary and translational medicine

John C. Schwartz, Johanneke Hemmink, Simon P. Graham, Elma Tchilian, Bryan Charleston, Sabine E. Hammer, Chak-Sum Ho, John A. Hammond

Research output: Contribution to journalComment/debatepeer-review

Abstract

The Babraham pig is a highly inbred breed first developed in the United Kingdom
approximately 50 years ago. Previous reports indicate a very high degree of homozygosity across the genome, including the MHC region, but confirmation of homozygosity at thespecific MHC loci was lacking. Using both direct sequencing and PCR-based sequence specific typing, we confirm that Babraham pigs are essentially homozygous at their MHC loci and formalize their MHC haplotype as Hp-55.6. This enhances the utility of the Babraham pig as a useful biomedical model for studies in which controlling for genetic
35 variation is important.
Original languageEnglish
Pages (from-to)40-43
JournalTissue antigens
Volume92
Issue number1
Early online date23 Apr 2018
DOIs
Publication statusPublished - Jul 2018

Keywords

  • genotyping
  • SSP typing
  • Sus scrofa
  • swine leukocyte antigen
  • SLA

Fingerprint

Dive into the research topics of 'The major histocompatibility complex homozygous inbred Babraham pig as a resource for veterinary and translational medicine'. Together they form a unique fingerprint.

Cite this