Abstract
AIMS: The aim of this retrospective analysis was to review the outcome of patients with germ-cell tumours treated in the Edinburgh Cancer Centre over the past 15 years, and to see whether there had been any changes over three 5-year cohorts.
MATERIALS AND METHODS: Patients referred with gonadal and extra-gonadal primary germ-cell tumours, between 1988 and 2002, were identified from the departmental database, and survival by stage and prognostic group was analysed.
RESULTS AND CONCLUSIONS: The proportion of patients with stage I seminoma has significantly increased. The good prognosis of patients with early stage disease is confirmed, with the outcome for some groups of patients being better than expected. There is a non-significant trend to improved results over the three 5-year cohorts. The outcome for patients with stage IV seminoma is worse than would be expected, but numbers are small. The poor prognosis of patients with non-seminomatous germ-cell tumours who fall into the International Germ Cell Consensus Classification (IGCCC) poor-prognostic group is confirmed. Failure of patients with metastatic non-seminomatous germ-cell tumours to achieve a complete response to initial therapy is shown to be a poor prognostic indicator.
Original language | English |
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Pages (from-to) | 435-40 |
Number of pages | 6 |
Journal | Clinical Oncology |
Volume | 17 |
Issue number | 6 |
Publication status | Published - Sep 2005 |
Keywords
- Adolescent
- Adult
- Aged
- Combined Modality Therapy
- Disease-Free Survival
- Humans
- Male
- Middle Aged
- Neoplasm Staging
- Neoplasms, Germ Cell and Embryonal/mortality
- Retrospective Studies
- Risk Factors
- Survival Rate
- Testicular Neoplasms/mortality
- Treatment Outcome