The management and outcome of patients with germ-cell tumours treated in the Edinburgh Cancer Centre between 1988 and 2002

G C W Howard, D S Conkey, S Peoples, D B McLaren, T B Hargreave, D N Tulloch, W Walker, G R Kerr

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

AIMS: The aim of this retrospective analysis was to review the outcome of patients with germ-cell tumours treated in the Edinburgh Cancer Centre over the past 15 years, and to see whether there had been any changes over three 5-year cohorts.

MATERIALS AND METHODS: Patients referred with gonadal and extra-gonadal primary germ-cell tumours, between 1988 and 2002, were identified from the departmental database, and survival by stage and prognostic group was analysed.

RESULTS AND CONCLUSIONS: The proportion of patients with stage I seminoma has significantly increased. The good prognosis of patients with early stage disease is confirmed, with the outcome for some groups of patients being better than expected. There is a non-significant trend to improved results over the three 5-year cohorts. The outcome for patients with stage IV seminoma is worse than would be expected, but numbers are small. The poor prognosis of patients with non-seminomatous germ-cell tumours who fall into the International Germ Cell Consensus Classification (IGCCC) poor-prognostic group is confirmed. Failure of patients with metastatic non-seminomatous germ-cell tumours to achieve a complete response to initial therapy is shown to be a poor prognostic indicator.

Original languageEnglish
Pages (from-to)435-40
Number of pages6
JournalClinical Oncology
Volume17
Issue number6
Publication statusPublished - Sept 2005

Keywords / Materials (for Non-textual outputs)

  • Adolescent
  • Adult
  • Aged
  • Combined Modality Therapy
  • Disease-Free Survival
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Neoplasms, Germ Cell and Embryonal/mortality
  • Retrospective Studies
  • Risk Factors
  • Survival Rate
  • Testicular Neoplasms/mortality
  • Treatment Outcome

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