The many roles of an RNA editor

L P Keegan; A Gallo; M A O'Connell

doi:10.1038/35098584

The many roles of an RNA editor

L P Keegan, A Gallo, M A O'Connell

Deanery of Molecular, Genetic and Population Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

The availability of complete genome sequences has made it clear that gene number is not the sole determinant of the complexity of the proteome. Additional complexity that is not readily detected by genome analysis is present in the number and types of RNA transcript that can be derived from each locus. Although alternative splicing is a well-recognized method of generating diversity, the more subtle mechanism of RNA editing is less familiar.

Original language	English
Pages (from-to)	869-78
Number of pages	10
Journal	Nature Reviews Genetics
Volume	2
Issue number	11
DOIs	https://doi.org/10.1038/35098584
Publication status	Published - 2001

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abstract = "The availability of complete genome sequences has made it clear that gene number is not the sole determinant of the complexity of the proteome. Additional complexity that is not readily detected by genome analysis is present in the number and types of RNA transcript that can be derived from each locus. Although alternative splicing is a well-recognized method of generating diversity, the more subtle mechanism of RNA editing is less familiar.",

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AB - The availability of complete genome sequences has made it clear that gene number is not the sole determinant of the complexity of the proteome. Additional complexity that is not readily detected by genome analysis is present in the number and types of RNA transcript that can be derived from each locus. Although alternative splicing is a well-recognized method of generating diversity, the more subtle mechanism of RNA editing is less familiar.

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DO - 10.1038/35098584

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JO - Nature Reviews Genetics

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The many roles of an RNA editor

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