The melanocyte lineage in development and disease

Richard L Mort, Ian J Jackson, E Elizabeth Patton

Research output: Contribution to journalArticlepeer-review

Abstract

Melanocyte development provides an excellent model for studying more complex developmental processes. Melanocytes have an apparently simple aetiology, differentiating from the neural crest and migrating through the developing embryo to specific locations within the skin and hair follicles, and to other sites in the body. The study of pigmentation mutations in the mouse provided the initial key to identifying the genes and proteins involved in melanocyte development. In addition, work on chicken has provided important embryological and molecular insights, whereas studies in zebrafish have allowed live imaging as well as genetic and transgenic approaches. This cross-species approach is powerful and, as we review here, has resulted in a detailed understanding of melanocyte development and differentiation, melanocyte stem cells and the role of the melanocyte lineage in diseases such as melanoma.

Original languageEnglish
Pages (from-to)620-632
Number of pages13
JournalDevelopment
Volume142
Issue number4
DOIs
Publication statusPublished - 15 Feb 2015

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