The metazoan history of the COE transcription factors. Selection of a variant HLH motif by mandatory inclusion of a duplicated exon in vertebrates

Virginie Daburon, Sébastien Mella, Jean-Louis Plouhinec, Sylvie Mazan, Michèle Crozatier, Alain Vincent

Research output: Contribution to journalArticlepeer-review

Abstract

The increasing number of available genomic sequences makes it now possible to study the evolutionary history of specific genes or gene families. Transcription factors (TFs) involved in regulation of gene-specific expression are key players in the evolution of metazoan development. The low complexity COE (Collier/Olfactory-1/Early B-Cell Factor) family of transcription factors constitutes a well-suited paradigm for studying evolution of TF structure and function, including the specific question of protein modularity. Here, we compare the structure of coe genes within the metazoan kingdom and report on the mechanism behind a vertebrate-specific exon duplication.
Original languageEnglish
Pages (from-to)131
JournalBMC Evolutionary Biology
Volume8
DOIs
Publication statusPublished - 2008

Keywords

  • Amino Acid Sequence
  • Animals
  • Basic Helix-Loop-Helix Transcription Factors
  • Bayes Theorem
  • Drosophila
  • Evolution, Molecular
  • Exons
  • Helix-Loop-Helix Motifs
  • Phylogeny
  • Sequence Alignment
  • Transcription Factors
  • Vertebrates

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