The mini-addenbrooke's cognitive examination: A new assessment tool for dementia

Sharpley Hsieh*, Sarah McGrory, Felicity Leslie, Kate Dawson, Samrah Ahmed, Chris R. Butler, James B. Rowe, Eneida Mioshi, John R. Hodges

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Background/Aims: We developed and validated the Mini-Addenbrooke's Cognitive Examination (M-ACE) in dementia patients. Comparisons were also made with the Mini Mental State Examination (MMSE). Method: The M-ACE was developed using Mokken scaling analysis in 117 dementia patients [behavioural variant frontotemporal dementia (bvFTD), n = 25; primary progressive aphasia (PPA), n = 49; Alzheimer's disease (AD), n = 34; corticobasal syndrome (CBS), n = 9] and validated in an independent sample of 164 dementia patients (bvFTD, n = 23; PPA, n = 82; AD, n = 38; CBS, n = 21) and 78 controls, who also completed the MMSE. Results: The M-ACE consists of 5 items with a maximum score of 30. Two cut-offs were identified: (1) ≤25/30 has both high sensitivity and specificity, and (2) ≤21/30 is almost certainly a score to have come from a dementia patient regardless of the clinical setting. The M-ACE is more sensitive than the MMSE and is less likely to have ceiling effects. Conclusion: The M-ACE is a brief and sensitive cognitive screening tool for dementia. Two cut-offs (25 or 21) are recommended.

Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalDementia and Geriatric Cognitive Disorders
Publication statusPublished - 4 Feb 2015

Keywords / Materials (for Non-textual outputs)

  • Alzheimer's disease
  • Cognitive screening test
  • Corticobasal degeneration
  • Frontotemporal dementia


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