The molecular basis of MeCP2 function in the brain

Rebekah Tillotson, Adrian Bird

Research output: Contribution to journalArticlepeer-review

Abstract

MeCP2 is a reader of the DNA methylome that occupies a large proportion of the genome due to its high abundance and the frequency of its target sites. It has been the subject of extensive study due to its link with ‘MECP2-related disorders’, of which Rett syndrome is the most prevalent. This review integrates evidence from patient mutation data with results of experimental studies using mouse models, cell lines and in vitro systems to critically evaluate our understanding of MeCP2 protein function. Recent evidence challenges the idea the MeCP2 is a multifunctional hub that integrates diverse processes to underpin neuronal function, suggesting instead that its primary role is to recruit the NCoR1/2 co-repressor complex to methylated sites in the genome, leading to dampening of gene expression.
Original languageEnglish
JournalJournal of Molecular Biology
Volume432
Issue number6
DOIs
Publication statusPublished - 13 Mar 2020

Keywords

  • MeCP2
  • Rett syndrome
  • DNA methylation
  • Transcriptional regulation
  • Neurological function

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