The molecular mechanisms of skeletal muscle wasting: implications for therapy

R J E Skipworth, G D Stewart, J A Ross, D C Guttridge, K C H Fearon

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Skeletal muscle wasting is an important systemic manifestation of a wide range of diseases, including trauma, sepsis and cancer. The clinical consequences of muscle wasting undoubtedly include significant patient morbidity and worsened survival. Recently, there has been important progress in our understanding of the molecular mechanisms behind muscle wasting. In this review, the common systemic mediators, intracellular signalling pathways and effector mechanisms of skeletal muscle wasting are discussed with particular reference to different models of wasting and the development of novel therapeutic strategies.
Original languageEnglish
Pages (from-to)273-83
Number of pages11
JournalThe Surgeon
Issue number5
Publication statusPublished - 2006


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