The Molecular Pathology of Appendiceal Neoplasms

Amy Leeming, David Worrall, Mark Arends

Research output: Contribution to journalArticlepeer-review


Here we review the molecular pathological changes of appendiceal neoplasms, in part using the consensus terminology agreed by the Peritoneal Surface Oncology Group International (PSOGI)1,2, with appendiceal neoplasms subcategorised as: hyperplastic polyps and serrated lesions (with and without dysplasia); appendiceal mucinous neoplasms (low and high grade); adenocarcinoma; goblet cell tumours; and neuroendocrine neoplasms. Compared with molecular pathological studies elsewhere in the gastrointestinal tract, the neoplasms of the appendix are less well investigated; however correlation of molecular pathology data with the revised histopathological subcategorisation provides improved understanding of the nature of these lesions, highlights some of the differences between them, and allows identification of actionable mutations that may help to guide future therapy.
Original languageEnglish
JournalAJSP: Reviews & Reports
Publication statusPublished - 1 May 2019


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