The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80: macrophages of bone and associated connective tissue

D A Hume, J F Loutit, S Gordon

Research output: Contribution to journalArticlepeer-review

Abstract

The macrophage-specific antigen F4/80 has been localized in adult mouse bone and connective tissue. F4/80 positive cells form the centre of haemopoietic islands, line the periosteal and subendosteal bone surfaces and are a major component of connective tissue and the synovial membrane (presumptive type A cells). F4/80 is absent from fibroblasts, chondrocytes, osteoblasts, osteocytes, osteoclasts and a subpopulation of synovial lining cells (presumptive type B cells).
Original languageEnglish
Pages (from-to)189-94
Number of pages6
JournalJournal of Cell Science
Volume66
Publication statusPublished - Mar 1984

Keywords

  • Animals
  • Antigens
  • Bone and Bones
  • Connective Tissue
  • Immunoenzyme Techniques
  • Macrophages
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Osteoclasts
  • Synovial Membrane

Fingerprint Dive into the research topics of 'The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80: macrophages of bone and associated connective tissue'. Together they form a unique fingerprint.

Cite this