The mosaic genome of indigenous African cattle as a unique genetic resource for African pastoralism

Kwondo Kim; Taehyung Kwon; Tadelle Dessie; DongAhn Yoo; Okeyo Ally Mwai; Jisung Jang; Samsun Sung; SaetByeol Lee; Bashir Salim; Jaehoon Jung; Heesu Jeong; Getinet Mekuriaw Tarekegn; Abdulfatai Tijjani; Dajeong Lim; Seoae Cho; Sung Jong Oh; Hak-Kyo Lee; Jaemin Kim; Choongwon Jeong; Stephen Kemp; Olivier Hanotte; Heebal Kim

doi:10.1038/s41588-020-0694-2

The mosaic genome of indigenous African cattle as a unique genetic resource for African pastoralism

Kwondo Kim, Taehyung Kwon, Tadelle Dessie, DongAhn Yoo, Okeyo Ally Mwai, Jisung Jang, Samsun Sung, SaetByeol Lee, Bashir Salim, Jaehoon Jung, Heesu Jeong, Getinet Mekuriaw Tarekegn, Abdulfatai Tijjani, Dajeong Lim, Seoae Cho, Sung Jong Oh, Hak-Kyo Lee, Jaemin Kim, Choongwon Jeong, Stephen KempOlivier Hanotte, Heebal Kim

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Abstract / Description of output

Cattle pastoralism plays a central role in human livelihood in Africa. However, the genetic history of its success remains unknown. Here, through whole-genome sequence analysis of 172 indigenous African cattle from 16 breeds representative of the main cattle groups, we identify a major taurine × indicine cattle admixture event dated to circa 750-1,050 yr ago, which has shaped the genome of today's cattle in the Horn of Africa. We identify 16 loci linked to African environmental adaptations across crossbred animals showing an excess of taurine or indicine ancestry. These include immune-, heat-tolerance- and reproduction-related genes. Moreover, we identify one highly divergent locus in African taurine cattle, which is putatively linked to trypanotolerance and present in crossbred cattle living in trypanosomosis-infested areas. Our findings indicate that a combination of past taurine and recent indicine admixture-derived genetic resources is at the root of the present success of African pastoralism.

Original language	English
Pages (from-to)	1099-1110
Number of pages	12
Journal	Nature Genetics
Volume	52
Issue number	10
DOIs	https://doi.org/10.1038/s41588-020-0694-2
Publication status	Published - 28 Sept 2020

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The mosaic genome of indigenous African cattle as a unique genetic resource for African pastoralismAccepted author manuscript, 345 KB

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Kim, K., Kwon, T., Dessie, T., Yoo, D., Mwai, O. A., Jang, J., Sung, S., Lee, S., Salim, B., Jung, J., Jeong, H., Tarekegn, G. M., Tijjani, A., Lim, D., Cho, S., Oh, S. J., Lee, H.-K., Kim, J., Jeong, C., ... Kim, H. (2020). The mosaic genome of indigenous African cattle as a unique genetic resource for African pastoralism. Nature Genetics, 52(10), 1099-1110. https://doi.org/10.1038/s41588-020-0694-2

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title = "The mosaic genome of indigenous African cattle as a unique genetic resource for African pastoralism",

abstract = "Cattle pastoralism plays a central role in human livelihood in Africa. However, the genetic history of its success remains unknown. Here, through whole-genome sequence analysis of 172 indigenous African cattle from 16 breeds representative of the main cattle groups, we identify a major taurine × indicine cattle admixture event dated to circa 750-1,050 yr ago, which has shaped the genome of today's cattle in the Horn of Africa. We identify 16 loci linked to African environmental adaptations across crossbred animals showing an excess of taurine or indicine ancestry. These include immune-, heat-tolerance- and reproduction-related genes. Moreover, we identify one highly divergent locus in African taurine cattle, which is putatively linked to trypanotolerance and present in crossbred cattle living in trypanosomosis-infested areas. Our findings indicate that a combination of past taurine and recent indicine admixture-derived genetic resources is at the root of the present success of African pastoralism.",

author = "Kwondo Kim and Taehyung Kwon and Tadelle Dessie and DongAhn Yoo and Mwai, {Okeyo Ally} and Jisung Jang and Samsun Sung and SaetByeol Lee and Bashir Salim and Jaehoon Jung and Heesu Jeong and Tarekegn, {Getinet Mekuriaw} and Abdulfatai Tijjani and Dajeong Lim and Seoae Cho and Oh, {Sung Jong} and Hak-Kyo Lee and Jaemin Kim and Choongwon Jeong and Stephen Kemp and Olivier Hanotte and Heebal Kim",

year = "2020",

month = sep,

day = "28",

doi = "10.1038/s41588-020-0694-2",

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Kim, K, Kwon, T, Dessie, T, Yoo, D, Mwai, OA, Jang, J, Sung, S, Lee, S, Salim, B, Jung, J, Jeong, H, Tarekegn, GM, Tijjani, A, Lim, D, Cho, S, Oh, SJ, Lee, H-K, Kim, J, Jeong, C, Kemp, S, Hanotte, O & Kim, H 2020, 'The mosaic genome of indigenous African cattle as a unique genetic resource for African pastoralism', Nature Genetics, vol. 52, no. 10, pp. 1099-1110. https://doi.org/10.1038/s41588-020-0694-2

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T1 - The mosaic genome of indigenous African cattle as a unique genetic resource for African pastoralism

AU - Kim, Kwondo

AU - Kwon, Taehyung

AU - Dessie, Tadelle

AU - Yoo, DongAhn

AU - Mwai, Okeyo Ally

AU - Jang, Jisung

AU - Sung, Samsun

AU - Lee, SaetByeol

AU - Salim, Bashir

AU - Jung, Jaehoon

AU - Jeong, Heesu

AU - Tarekegn, Getinet Mekuriaw

AU - Tijjani, Abdulfatai

AU - Lim, Dajeong

AU - Cho, Seoae

AU - Oh, Sung Jong

AU - Lee, Hak-Kyo

AU - Kim, Jaemin

AU - Jeong, Choongwon

AU - Kemp, Stephen

AU - Hanotte, Olivier

AU - Kim, Heebal

PY - 2020/9/28

Y1 - 2020/9/28

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AB - Cattle pastoralism plays a central role in human livelihood in Africa. However, the genetic history of its success remains unknown. Here, through whole-genome sequence analysis of 172 indigenous African cattle from 16 breeds representative of the main cattle groups, we identify a major taurine × indicine cattle admixture event dated to circa 750-1,050 yr ago, which has shaped the genome of today's cattle in the Horn of Africa. We identify 16 loci linked to African environmental adaptations across crossbred animals showing an excess of taurine or indicine ancestry. These include immune-, heat-tolerance- and reproduction-related genes. Moreover, we identify one highly divergent locus in African taurine cattle, which is putatively linked to trypanotolerance and present in crossbred cattle living in trypanosomosis-infested areas. Our findings indicate that a combination of past taurine and recent indicine admixture-derived genetic resources is at the root of the present success of African pastoralism.

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DO - 10.1038/s41588-020-0694-2

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C2 - 32989325

SN - 1061-4036

VL - 52

SP - 1099

EP - 1110

JO - Nature Genetics

JF - Nature Genetics

IS - 10

ER -

The mosaic genome of indigenous African cattle as a unique genetic resource for African pastoralism

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