The mouse frizzled 8 receptor is expressed in anterior organizer tissues

CC Lu, EJ Robertson, J Brennan

Research output: Contribution to journalArticlepeer-review

Abstract

Wnt signaling has been shown to be important for axis formation in vertebrates. However, no Wnt ligand or receptor has been shown to be specifically expressed in all the organizer tissues in the mouse embryo. Here we report that the mouse frizzled 8 (mfz8) gene, a Wnt receptor, is expressed in the anterior visceral endoderm (AVE) and the anterior primitive streak, which have been shown to possess organizer activity. mFz8 is also expressed in the descendents of the anterior streak that comprise the anterior mesendoderm (AME) at midgastrulation, with subsequent expression in the anterior neurectoderm, which is specified and patterned by the AVE and AME. Thus, mfz8 is specifically expressed in the organizer tissues that establish the anterior-postenor axis in the mouse embryo. (C) 2004 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)569-572
Number of pages4
JournalGene Expression Patterns
Volume4
Issue number5
DOIs
Publication statusPublished - Sep 2004

Keywords

  • mouse
  • embryo
  • Wnt
  • frizzled
  • anterior visceral endoderm
  • anterior mesendoderm
  • organizer
  • gastrulation
  • primitive streak
  • axis formation
  • anterior-posterior
  • AXIS FORMATION
  • EMBRYONIC AXIS
  • HEAD INDUCTION
  • MORPHOGENESIS
  • PATHWAY
  • GENE

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