The mouse secretome: functional classification of the proteins secreted into the extracellular environment

RIKEN GER Group; Sean M Grimmond; Kevin C Miranda; Zheng Yuan; Melissa J Davis; David A Hume; Ken Yagi; Naoko Tominaga; Hidemasa Bono; Yoshihide Hayashizaki; Yasushi Okazaki; Rohan D Teasdale

doi:10.1101/gr.983703

The mouse secretome: functional classification of the proteins secreted into the extracellular environment

RIKEN GER Group, Sean M Grimmond, Kevin C Miranda, Zheng Yuan, Melissa J Davis, David A Hume, Ken Yagi, Naoko Tominaga, Hidemasa Bono, Yoshihide Hayashizaki, Yasushi Okazaki, Rohan D Teasdale

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

We have developed a computational strategy to identify the set of soluble proteins secreted into the extracellular environment of a cell. Within the protein sequences predominantly derived from the RIKEN representative transcript and protein set, we identified 2033 unique soluble proteins that are potentially secreted from the cell. These proteins contain a signal peptide required for entry into the secretory pathway and lack any transmembrane domains or intracellular localization signals. This class of proteins, which we have termed the mouse secretome, included >500 novel proteins and 92 proteins

Original language	English
Pages (from-to)	1350-9
Number of pages	10
Journal	Genome Research
Volume	13
Issue number	6B
DOIs	https://doi.org/10.1101/gr.983703
Publication status	Published - Jun 2003

Keywords

Animals
Cluster Analysis
Computational Biology
Databases, Genetic
Extracellular Space
Humans
Mice
Organ Specificity
Proteome
Sequence Homology, Nucleic Acid

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10.1101/gr.983703

The mouse secretome functional classification of the proteins secreted into the extracellular environment
2003 by Cold Spring Harbor Laboratory Press ISSN 1088-9051 /03 $5.00; www.genome.org
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AU - Miranda, Kevin C

AU - Yuan, Zheng

AU - Davis, Melissa J

AU - Hume, David A

AU - Yagi, Ken

AU - Tominaga, Naoko

AU - Bono, Hidemasa

AU - Hayashizaki, Yoshihide

AU - Okazaki, Yasushi

AU - Teasdale, Rohan D

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KW - Animals

KW - Cluster Analysis

KW - Computational Biology

KW - Databases, Genetic

KW - Extracellular Space

KW - Humans

KW - Mice

KW - Organ Specificity

KW - Proteome

KW - Sequence Homology, Nucleic Acid

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JO - Genome Research

JF - Genome Research

SN - 1088-9051

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The mouse secretome: functional classification of the proteins secreted into the extracellular environment

Abstract

Keywords

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