Abstract / Description of output
The transcription factor Gata3 is crucial for the development of several tissues
and cell lineages both during development as well as postnatally. This importance is
apparent from the early embryonic lethality following germline Gata3 deletion, with
embryos displaying a number of phenotypes, and from the fact that Gata3 has been
implicated in several cancer types. It often acts at the level of stem and progenitor cells in
which it controls the expression of key lineage-determining factors as well as cell cycle
genes, thus being one of the main drivers of cell fate choice and tissue morphogenesis.
Gata3 is involved at various stages of haematopoiesis both in the adult as well as during
development. This review summarises the various contributions of Gata3 to
haematopoiesis with a particular focus on the emergence of the first haematopoietic stem
cells in the embryo – a process that appears to be influenced by Gata3 at various levels,
thus highlighting the complex nature of Gata3 action.
and cell lineages both during development as well as postnatally. This importance is
apparent from the early embryonic lethality following germline Gata3 deletion, with
embryos displaying a number of phenotypes, and from the fact that Gata3 has been
implicated in several cancer types. It often acts at the level of stem and progenitor cells in
which it controls the expression of key lineage-determining factors as well as cell cycle
genes, thus being one of the main drivers of cell fate choice and tissue morphogenesis.
Gata3 is involved at various stages of haematopoiesis both in the adult as well as during
development. This review summarises the various contributions of Gata3 to
haematopoiesis with a particular focus on the emergence of the first haematopoietic stem
cells in the embryo – a process that appears to be influenced by Gata3 at various levels,
thus highlighting the complex nature of Gata3 action.
| Original language | English |
|---|---|
| Journal | Open Biology |
| Early online date | 1 Nov 2018 |
| DOIs | |
| Publication status | E-pub ahead of print - 1 Nov 2018 |