The multifaceted functions of ATG16L1 in autophagy and related processes

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Autophagy requires the formation of membrane vesicles, known as autophagosomes, that engulf cellular cargoes and subsequently recruit lysosomal hydrolases for the degradation of their contents. A
number of proteins are required for autophagy that act to mediate the de novo biogenesis of autophagosomes and vesicular trafficking events. Of these proteins, ATG16L1 is a key player that has important functions at various stages of autophagy. Numerous recent studies have begun to unravel novel activities of ATG16L1, including interactions with proteins and lipids, and how these mediate its role during autophagy and autophagy-related processes. Various domains have been identified within ATG16L1 that mediate its functions in recognising single and double membranes and activating subsequent autophagy-related enzymatic activities required for the recruitment of lysosomes. These
recent findings, as well as the historical discovery of ATG16L1, pathological relevance, unresolved questions and contradictory observations, will be discussed here.
Original languageEnglish
JournalJournal of Cell Science
Early online date30 Oct 2020
DOIs
Publication statusE-pub ahead of print - 30 Oct 2020

Keywords / Materials (for Non-textual outputs)

  • autophagy
  • autophagosome
  • phagophore
  • ATG16L1
  • Atg16
  • lipid binding
  • membrane recruitment
  • single membrane lipidation

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