The Multifaceted Role of Perivascular Macrophages in Tumors

Evidence has emerged for macrophages in the perivascular niche of tumors regulating important processes like angiogenesis, key events in the metastatic cascade, the recruitment and activity of other tumor-promoting leukocytes and tumor responses to the frontline therapies, irradiation and chemotherapy. Understanding the mechanisms controlling the recruitment, retention and function of these cells could lead to major targets for new anti-cancer therapeutics.