The NAD metabolome - a key determinant of cancer cell biology

Alberto Chiarugi, Christian Dolle, Roberta Felici, Mathias Ziegler*

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

NAD is a vital molecule in all organisms. It is a key component of both energy and signal transduction - processes that undergo crucial changes in cancer cells. NAD(+)-dependent signalling pathways are many and varied, and they regulate fundamental events such as transcription, DNA repair, cell cycle progression, apoptosis and metabolism. Many of these processes have been linked to cancer development. Given that NAD(+)-dependent signalling reactions involve the degradation of the molecule, permanent nucleotide resynthesis through different biosynthetic pathways is crucial for incessant cancer cell proliferation. This necessity supports the targeting of NAD metabolism as a new therapeutic concept for cancer treatment.

Original languageEnglish
Pages (from-to)741-752
Number of pages12
JournalNature Reviews Cancer
Volume12
Issue number11
DOIs
Publication statusPublished - Nov 2012

Keywords

  • NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE
  • INDUCIBLE FACTOR 1-ALPHA
  • COLONY-ENHANCING FACTOR
  • POLY(ADP-RIBOSE) POLYMERASE
  • DIPHOSPHOPYRIDINE NUCLEOTIDE
  • ADP-RIBOSE
  • SIRTUIN 1
  • PHASE-I
  • SUBCELLULAR COMPARTMENTATION
  • DEACETYLASE ACTIVITY

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