The need for translational research on antidotes for pesticide poisoning

Nick A Buckley, Michael Eddleston, Andrew H Dawson

Research output: Contribution to journalArticlepeer-review


1. Pesticide poisoning kills hundreds of thousands of people in the Asia-Pacific region each year. The majority of deaths are from deliberate self-poisoning with organophosphorus pesticides (OP), aluminium phosphide and paraquat. The current response from a public health, medical and research perspective is inadequate. 2. There are few proven or effective treatments; in addition, very little clinical research has been performed to transfer antidotes shown to work in animal studies into clinical practice. 3. The human toxicity of pesticides is poorly studied and better information may inform a more sustained and appropriate regulatory response. Further understanding may also lead to improvements in diagnosis and treatment. 4. The few effective treatments are not being recommended or delivered in an optimal and timely fashion to poisoned patients. A regional approach to facilitate appropriate pricing, packaging and delivery of antidotes is required.

Original languageEnglish
Pages (from-to)999-1005
Number of pages7
JournalClinical and Experimental Pharmacology and Physiology
Issue number11
Publication statusPublished - Nov 2005


  • Animals
  • Antidotes
  • Cholinesterase Inhibitors
  • Humans
  • Immunosuppressive Agents
  • Organophosphate Poisoning
  • Oximes
  • Paraquat
  • Pesticides
  • Poisoning
  • Public Health
  • Sodium Bicarbonate
  • Sri Lanka


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