Projects per year
Abstract
Human Genome Wide Association Studies have linked SNPs in NEMP1 (Nuclear Envelope Membrane Protein 1) with early menopause (1,2), however it is unclear if NEMP1 has any role in fertility. We show that whole animal loss of NEMP1 homologs in Drosophila, C. elegans, zebrafish and mice lead to sterility or early loss of fertility. Loss of Nemp leads to nuclear shaping defects, most prominently in the germline. Biochemical, biophysical and genetic studies reveal NEMP proteins support the mechanical stiffness of the germline nuclear envelope via formation of a NEMP
EMERIN complex. These data indicate that the germline nuclear envelope has specialized mechanical properties, and that NEMP proteins play essential and conserved roles in fertility.
EMERIN complex. These data indicate that the germline nuclear envelope has specialized mechanical properties, and that NEMP proteins play essential and conserved roles in fertility.
Original language | English |
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Article number | eabb4591 |
Journal | Science Advances |
Volume | 6 |
DOIs | |
Publication status | Published - 28 Aug 2020 |
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Dive into the research topics of 'The NEMP family supports metazoan fertility and nuclear envelope stiffness'. Together they form a unique fingerprint.Projects
- 2 Finished
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Core funding renewal for the Wellcome Trust Centre for Cell Biology
Tollervey, D. (Principal Investigator) & Earnshaw, B. (Co-investigator)
1/10/11 → 30/04/17
Project: Research
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Nuclear envelope transmembrane protein regulation of tissue-specific genome organisation and cell cycle regulation
Schirmer, E. (Principal Investigator)
1/08/11 → 31/07/19
Project: Research