The neuroendocrine stress hormone norepinephrine augments Escherichia coli O157 : H7-induced enteritis and adherence in a bovine ligated ileal loop model of infection

I  Vlisidou; M  Lyte; P M  van Diemen; P  Hawes; P  Monaghan; T S  Wallis; M P  Stevens

doi:10.1128/IAI.72.9.5446-5451.2004

The neuroendocrine stress hormone norepinephrine augments Escherichia coli O157 : H7-induced enteritis and adherence in a bovine ligated ileal loop model of infection

I Vlisidou, M Lyte, P M van Diemen, P Hawes, P Monaghan, T S Wallis, M P Stevens

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

The role of the neuroendocrine environment in the pathogenesis of enteric bacterial infections is increasingly being recognized. Here we report that norepinephrine augments Escherichia coli O157:H7-induced intestinal inflammatory and secretory responses as well as bacterial adherence to intestinal mucosa in a bovine ligated ileal loop model of infection. Norepinephrine modulation of enteritis and adherence was dependent on the ability of E. coli O157:H7 to form attaching and effacing lesions.

Original language	English
Pages (from-to)	5446-5451
Number of pages	6
Journal	Infection and Immunity
Volume	72
Issue number	9
DOIs	https://doi.org/10.1128/IAI.72.9.5446-5451.2004
Publication status	Published - Sept 2004

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10.1128/IAI.72.9.5446-5451.2004

The neuroendocrine stress hormone norepinephrine augments Escherichia coli O157 H7-induced enteritis and adherence in a bovine ligated ileal loop model of infection
Copyright © 2004, American Society for Microbiology
Final published version, 1.84 MB

http://iai.asm.org/content/72/9/5446

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abstract = "The role of the neuroendocrine environment in the pathogenesis of enteric bacterial infections is increasingly being recognized. Here we report that norepinephrine augments Escherichia coli O157:H7-induced intestinal inflammatory and secretory responses as well as bacterial adherence to intestinal mucosa in a bovine ligated ileal loop model of infection. Norepinephrine modulation of enteritis and adherence was dependent on the ability of E. coli O157:H7 to form attaching and effacing lesions.",

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AU - Vlisidou, I

AU - Lyte, M

AU - van Diemen, P M

AU - Hawes, P

AU - Monaghan, P

AU - Wallis, T S

AU - Stevens, M P

PY - 2004/9

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AB - The role of the neuroendocrine environment in the pathogenesis of enteric bacterial infections is increasingly being recognized. Here we report that norepinephrine augments Escherichia coli O157:H7-induced intestinal inflammatory and secretory responses as well as bacterial adherence to intestinal mucosa in a bovine ligated ileal loop model of infection. Norepinephrine modulation of enteritis and adherence was dependent on the ability of E. coli O157:H7 to form attaching and effacing lesions.

UR - https://www.scopus.com/pages/publications/4544348320

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DO - 10.1128/IAI.72.9.5446-5451.2004

M3 - Article

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SP - 5446

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JF - Infection and Immunity

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ER -

The neuroendocrine stress hormone norepinephrine augments Escherichia coli O157 : H7-induced enteritis and adherence in a bovine ligated ileal loop model of infection

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