Abstract / Description of output
The Noc1-4p proteins were previously reported to be involved in intranuclear and nucleocytoplasmic transport of pre-ribosomes. Using fold recognition and structural modeling, we show that Noc1-4p are largely comprised of alpha-helical repeats similar to HEAT repeats. Because other HEAT-repeat proteins play key roles in transport processes, this finding provides a plausible mechanistic explanation for the function of the Noc proteins.
Original language | English |
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Pages (from-to) | 351-354 |
Number of pages | 4 |
Journal | RNA |
Volume | 10 |
Issue number | 3 |
DOIs | |
Publication status | Published - Mar 2004 |
Keywords / Materials (for Non-textual outputs)
- rRNA
- ribosome formation
- ribonucleoproteins
- molecular models
- yeast