The Noc proteins involved in ribosome synthesis and export contain divergent HEAT repeats

M Dlakic, D Tollervey

Research output: Contribution to journalArticlepeer-review

Abstract

The Noc1-4p proteins were previously reported to be involved in intranuclear and nucleocytoplasmic transport of pre-ribosomes. Using fold recognition and structural modeling, we show that Noc1-4p are largely comprised of alpha-helical repeats similar to HEAT repeats. Because other HEAT-repeat proteins play key roles in transport processes, this finding provides a plausible mechanistic explanation for the function of the Noc proteins.

Original languageEnglish
Pages (from-to)351-354
Number of pages4
JournalRNA
Volume10
Issue number3
DOIs
Publication statusPublished - Mar 2004

Keywords

  • rRNA
  • ribosome formation
  • ribonucleoproteins
  • molecular models
  • yeast

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