The Notch and Sonic hedgehog signalling pathways in immunity

Robert A Benson; Jacqueline A Lowrey; Jonathan R Lamb; Sarah E M Howie

doi:10.1016/j.molimm.2004.04.017

The Notch and Sonic hedgehog signalling pathways in immunity

Robert A Benson, Jacqueline A Lowrey, Jonathan R Lamb, Sarah E M Howie

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

There is an increasing body of knowledge demonstrating that genes involved in cell fate decisions during development also play a role in the continuous cell fate decisions made by the mature immune system in response to foreign antigen. This review concentrates on the role of the Notch and Sonic hedgehog (Shh) signalling pathways in the development and function of CD4+ T lymphocytes.

Original language	English
Pages (from-to)	715-25
Number of pages	11
Journal	Molecular Immunology
Volume	41
Issue number	6-7
DOIs	https://doi.org/10.1016/j.molimm.2004.04.017
Publication status	Published - Jul 2004

Keywords / Materials (for Non-textual outputs)

Animals
CD4-Positive T-Lymphocytes
Cell Differentiation
Hedgehog Proteins
Humans
Immune System
Membrane Proteins
Neoplasms
Pneumonia
Receptors, Notch
Signal Transduction
Trans-Activators

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10.1016/j.molimm.2004.04.017

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title = "The Notch and Sonic hedgehog signalling pathways in immunity",

abstract = "There is an increasing body of knowledge demonstrating that genes involved in cell fate decisions during development also play a role in the continuous cell fate decisions made by the mature immune system in response to foreign antigen. This review concentrates on the role of the Notch and Sonic hedgehog (Shh) signalling pathways in the development and function of CD4+ T lymphocytes.",

keywords = "Animals, CD4-Positive T-Lymphocytes, Cell Differentiation, Hedgehog Proteins, Humans, Immune System, Membrane Proteins, Neoplasms, Pneumonia, Receptors, Notch, Signal Transduction, Trans-Activators",

author = "Benson, {Robert A} and Lowrey, {Jacqueline A} and Lamb, {Jonathan R} and Howie, {Sarah E M}",

year = "2004",

month = jul,

doi = "10.1016/j.molimm.2004.04.017",

language = "English",

volume = "41",

pages = "715--25",

journal = "Molecular Immunology",

issn = "0161-5890",

publisher = "Elsevier Limited",

number = "6-7",

}

TY - JOUR

T1 - The Notch and Sonic hedgehog signalling pathways in immunity

AU - Benson, Robert A

AU - Lowrey, Jacqueline A

AU - Lamb, Jonathan R

AU - Howie, Sarah E M

PY - 2004/7

Y1 - 2004/7

N2 - There is an increasing body of knowledge demonstrating that genes involved in cell fate decisions during development also play a role in the continuous cell fate decisions made by the mature immune system in response to foreign antigen. This review concentrates on the role of the Notch and Sonic hedgehog (Shh) signalling pathways in the development and function of CD4+ T lymphocytes.

AB - There is an increasing body of knowledge demonstrating that genes involved in cell fate decisions during development also play a role in the continuous cell fate decisions made by the mature immune system in response to foreign antigen. This review concentrates on the role of the Notch and Sonic hedgehog (Shh) signalling pathways in the development and function of CD4+ T lymphocytes.

KW - Animals

KW - CD4-Positive T-Lymphocytes

KW - Cell Differentiation

KW - Hedgehog Proteins

KW - Humans

KW - Immune System

KW - Membrane Proteins

KW - Neoplasms

KW - Pneumonia

KW - Receptors, Notch

KW - Signal Transduction

KW - Trans-Activators

U2 - 10.1016/j.molimm.2004.04.017

DO - 10.1016/j.molimm.2004.04.017

M3 - Article

C2 - 15220006

SN - 0161-5890

VL - 41

SP - 715

EP - 725

JO - Molecular Immunology

JF - Molecular Immunology

IS - 6-7

ER -

The Notch and Sonic hedgehog signalling pathways in immunity

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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