The Notch and Sonic hedgehog signalling pathways in immunity

Robert A Benson, Jacqueline A Lowrey, Jonathan R Lamb, Sarah E M Howie

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

There is an increasing body of knowledge demonstrating that genes involved in cell fate decisions during development also play a role in the continuous cell fate decisions made by the mature immune system in response to foreign antigen. This review concentrates on the role of the Notch and Sonic hedgehog (Shh) signalling pathways in the development and function of CD4+ T lymphocytes.
Original languageEnglish
Pages (from-to)715-25
Number of pages11
JournalMolecular Immunology
Issue number6-7
Publication statusPublished - Jul 2004

Keywords / Materials (for Non-textual outputs)

  • Animals
  • CD4-Positive T-Lymphocytes
  • Cell Differentiation
  • Hedgehog Proteins
  • Humans
  • Immune System
  • Membrane Proteins
  • Neoplasms
  • Pneumonia
  • Receptors, Notch
  • Signal Transduction
  • Trans-Activators


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