The novel nucleoside analogue ProTide NUC-7738 overcomes cancer resistance mechanisms in vitro and in a first-in-human Phase 1 clinical trial

Hagen Schwenzer; Erica De Zan; Mustafa Elshani; Ruud Van Stiphout; Mary Kudsy; Josephine Morris; Valentina Ferrari; In Hwa Um; James Chettle; Farasat Kazmi; Leticia Campo; Alistair Easton; Sebastian Nijman; Michaela Serpi; Stefan Symeonides; Ruth Plummer; David J. Harrison; Gareth Bond; Sarah P. Blagden

doi:10.1158/1078-0432.CCR-21-1652

The novel nucleoside analogue ProTide NUC-7738 overcomes cancer resistance mechanisms in vitro and in a first-in-human Phase 1 clinical trial

Hagen Schwenzer, Erica De Zan, Mustafa Elshani, Ruud Van Stiphout, Mary Kudsy, Josephine Morris, Valentina Ferrari, In Hwa Um, James Chettle, Farasat Kazmi, Leticia Campo, Alistair Easton, Sebastian Nijman, Michaela Serpi, Stefan Symeonides, Ruth Plummer, David J. Harrison, Gareth Bond, Sarah P. Blagden

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	clincanres.1652.2021
Journal	Clinical Cancer Research
DOIs	https://doi.org/10.1158/1078-0432.CCR-21-1652 https://doi.org/doi: 10.1158/1078-0432.CCR-21-1652
Publication status	Published - 8 Sept 2021

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This is a pre-copyedited, author-produced version of an article accepted for publication in Clinical Cancer Research following peer review. The version of record "The novel nucleoside analogue ProTide NUC-7738 overcomes cancer resistance mechanisms in vitro and in a first-in-human Phase 1 clinical trial" is available online at: doi: 10.1158/1078-0432.CCR-21-1652
Accepted author manuscript, 5.16 MB

http://clincancerres.aacrjournals.org/lookup/doi/10.1158/1078-0432.CCR-21-1652

Cite this

Schwenzer, H., De Zan, E., Elshani, M., Van Stiphout, R., Kudsy, M., Morris, J., Ferrari, V., Um, I. H., Chettle, J., Kazmi, F., Campo, L., Easton, A., Nijman, S., Serpi, M., Symeonides, S., Plummer, R., Harrison, D. J., Bond, G., & Blagden, S. P. (2021). The novel nucleoside analogue ProTide NUC-7738 overcomes cancer resistance mechanisms in vitro and in a first-in-human Phase 1 clinical trial. Clinical Cancer Research, clincanres.1652.2021. https://doi.org/10.1158/1078-0432.CCR-21-1652, https://doi.org/doi: 10.1158/1078-0432.CCR-21-1652

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title = "The novel nucleoside analogue ProTide NUC-7738 overcomes cancer resistance mechanisms in vitro and in a first-in-human Phase 1 clinical trial",

author = "Hagen Schwenzer and {De Zan}, Erica and Mustafa Elshani and {Van Stiphout}, Ruud and Mary Kudsy and Josephine Morris and Valentina Ferrari and Um, {In Hwa} and James Chettle and Farasat Kazmi and Leticia Campo and Alistair Easton and Sebastian Nijman and Michaela Serpi and Stefan Symeonides and Ruth Plummer and Harrison, {David J.} and Gareth Bond and Blagden, {Sarah P.}",

year = "2021",

month = sep,

day = "8",

doi = "10.1158/1078-0432.CCR-21-1652",

language = "English",

pages = "clincanres.1652.2021",

journal = "Clinical Cancer Research",

issn = "1078-0432",

publisher = "American Association for Cancer Research Inc.",

}

Schwenzer, H, De Zan, E, Elshani, M, Van Stiphout, R, Kudsy, M, Morris, J, Ferrari, V, Um, IH, Chettle, J, Kazmi, F, Campo, L, Easton, A, Nijman, S, Serpi, M, Symeonides, S, Plummer, R, Harrison, DJ, Bond, G & Blagden, SP 2021, 'The novel nucleoside analogue ProTide NUC-7738 overcomes cancer resistance mechanisms in vitro and in a first-in-human Phase 1 clinical trial', Clinical Cancer Research, pp. clincanres.1652.2021. https://doi.org/10.1158/1078-0432.CCR-21-1652, https://doi.org/doi: 10.1158/1078-0432.CCR-21-1652

TY - JOUR

T1 - The novel nucleoside analogue ProTide NUC-7738 overcomes cancer resistance mechanisms in vitro and in a first-in-human Phase 1 clinical trial

AU - Schwenzer, Hagen

AU - De Zan, Erica

AU - Elshani, Mustafa

AU - Van Stiphout, Ruud

AU - Kudsy, Mary

AU - Morris, Josephine

AU - Ferrari, Valentina

AU - Um, In Hwa

AU - Chettle, James

AU - Kazmi, Farasat

AU - Campo, Leticia

AU - Easton, Alistair

AU - Nijman, Sebastian

AU - Serpi, Michaela

AU - Symeonides, Stefan

AU - Plummer, Ruth

AU - Harrison, David J.

AU - Bond, Gareth

AU - Blagden, Sarah P.

PY - 2021/9/8

Y1 - 2021/9/8

U2 - 10.1158/1078-0432.CCR-21-1652

DO - 10.1158/1078-0432.CCR-21-1652

M3 - Article

SN - 1078-0432

SP - clincanres.1652.2021

JO - Clinical Cancer Research

JF - Clinical Cancer Research

ER -