The NPAS3 gene--emerging evidence for a role in psychiatric illness

B. S. Pickard; A. A. Pieper; D. J. Porteous; D. H. Blackwood; W. J. Muir

The NPAS3 gene--emerging evidence for a role in psychiatric illness

B. S. Pickard, A. A. Pieper, D. J. Porteous, D. H. Blackwood, W. J. Muir

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Abstract / Description of output

NPAS3 is a member of the basic helix-loop-helix PAS domain class of transcription factors expressed in the brain. Evidence from a human chromosomal rearrangement and a mouse knock-out strain suggest that it may play a part in the aetiology of psychiatric illness. In this review, we describe evolutionary constraints on the NPAS3 gene, relevant functional studies from a related gene and the behavioural and hippocampal neurogenesis deficit observed in the mutant mouse. In addition, we speculate on the physiological regulation of NPAS3 and whether NPAS3 gene variation contributes to psychiatric illness at the population level.

Original language	English
Pages (from-to)	439-448
Number of pages	10
Journal	Annals of Medicine
Volume	38
Issue number	6
Publication status	Published - 2006

Keywords / Materials (for Non-textual outputs)

Animals Behavior, Animal Brain/cytology Humans Mutation Nerve Tissue Proteins/*genetics Schizophrenia/*genetics Transcription Factors/*genetics

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title = "The NPAS3 gene--emerging evidence for a role in psychiatric illness",

abstract = "NPAS3 is a member of the basic helix-loop-helix PAS domain class of transcription factors expressed in the brain. Evidence from a human chromosomal rearrangement and a mouse knock-out strain suggest that it may play a part in the aetiology of psychiatric illness. In this review, we describe evolutionary constraints on the NPAS3 gene, relevant functional studies from a related gene and the behavioural and hippocampal neurogenesis deficit observed in the mutant mouse. In addition, we speculate on the physiological regulation of NPAS3 and whether NPAS3 gene variation contributes to psychiatric illness at the population level.",

keywords = "Animals Behavior, Animal Brain/cytology Humans Mutation Nerve Tissue Proteins/*genetics Schizophrenia/*genetics Transcription Factors/*genetics",

author = "Pickard, {B. S.} and Pieper, {A. A.} and Porteous, {D. J.} and Blackwood, {D. H.} and Muir, {W. J.}",

note = "The NPAS3 gene--emerging evidence for a role in psychiatric illness Journal Article Review Sweden eng",

year = "2006",

language = "English",

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pages = "439--448",

journal = "Annals of Medicine",

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TY - JOUR

T1 - The NPAS3 gene--emerging evidence for a role in psychiatric illness

AU - Pickard, B. S.

AU - Pieper, A. A.

AU - Porteous, D. J.

AU - Blackwood, D. H.

AU - Muir, W. J.

N1 - The NPAS3 gene--emerging evidence for a role in psychiatric illness Journal Article Review Sweden eng

PY - 2006

Y1 - 2006

N2 - NPAS3 is a member of the basic helix-loop-helix PAS domain class of transcription factors expressed in the brain. Evidence from a human chromosomal rearrangement and a mouse knock-out strain suggest that it may play a part in the aetiology of psychiatric illness. In this review, we describe evolutionary constraints on the NPAS3 gene, relevant functional studies from a related gene and the behavioural and hippocampal neurogenesis deficit observed in the mutant mouse. In addition, we speculate on the physiological regulation of NPAS3 and whether NPAS3 gene variation contributes to psychiatric illness at the population level.

AB - NPAS3 is a member of the basic helix-loop-helix PAS domain class of transcription factors expressed in the brain. Evidence from a human chromosomal rearrangement and a mouse knock-out strain suggest that it may play a part in the aetiology of psychiatric illness. In this review, we describe evolutionary constraints on the NPAS3 gene, relevant functional studies from a related gene and the behavioural and hippocampal neurogenesis deficit observed in the mutant mouse. In addition, we speculate on the physiological regulation of NPAS3 and whether NPAS3 gene variation contributes to psychiatric illness at the population level.

KW - Animals Behavior, Animal Brain/cytology Humans Mutation Nerve Tissue Proteins/genetics Schizophrenia/genetics Transcription Factors/genetics

M3 - Article

SN - 0785-3890

VL - 38

SP - 439

EP - 448

JO - Annals of Medicine

JF - Annals of Medicine

IS - 6

ER -

The NPAS3 gene--emerging evidence for a role in psychiatric illness

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Keywords / Materials (for Non-textual outputs)

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