The nuclear RNA surveillance machinery: The ncRNAs and genome structure in budding link between yeast?

Jonathan Houseley, David Tollervey

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

The TRAMP polyadenylation complexes have well-established functions in RNA surveillance, stimulating degradation by the 3' to 5' exonuclease activity of the exosome on a wide range of nuclear RNAs and RNA-protein complexes. Known targets include some of the non-protein coding RNA transcripts (neRNAs), which are apparently widely transcribed from yeast and mammalian genomes. We will discuss potential mechanisms of TRAMP recruitment and exosome activation during RNA surveillance and degradation. Less well-understood observations link both the TRAMP and exosome complexes to chromatin structure and DNA repair, and we will speculate on the potential significance of these activities. (c) 2008 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)239-246
Number of pages8
JournalBBA - Gene Regulatory Mechanisms
Volume1779
Issue number4
DOIs
Publication statusPublished - Apr 2008

Keywords

  • Poly(A) polymerase
  • TRAMP
  • ncRNA
  • chromatin
  • RNA surveillance

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