The number of clonal precursors of the follicular epithelium in the mouse ovary

Evelyn Telfer, J. D. Ansell, Helen Taylor, R. G. Gosden

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The number of clonal precursors of granulosa cells in mouse ovarian follicles has been estimated using a technique based on the phenomenon of random X-chromosome inactivation of somatic cells and the use of an X-linked alloenzyme variant of the glycolytic enzyme PGK-1. The granulosa cells of follicles were oligoclonal in origin and founded by small number of cells (about 5) which was consistent with histological observations. When the analysis was extended to two subcompartments of the follicle, the mural and cumulus granulosa cells, the results indicated that the cumulus and mural granulosa cells had a common origin.

Original languageEnglish
Pages (from-to)105-110
Number of pages6
JournalJournal of reproduction and fertility
Volume84
Issue number1
DOIs
Publication statusPublished - Sept 1988

Keywords / Materials (for Non-textual outputs)

  • granulosa cells
  • primordial follicles
  • phosphoglycerate kinase
  • ovary

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