The O(α,p)F reaction is an important part of the hot CNO cycle. We have measured cross sections for the F(p,p)F, F(p,p)F*, and F(p,α)O reactions in inverse kinematics using radioactive F beams from the Holifield Radioactive Ion Beam Facility. The properties of states in Ne, including those important for the O(α,p F reaction rate, were determined from an R-matrix analysis of the measured cross sections. An improved O(α,p F reaction rate has been determined. The hot CNO cycle of reactions is important in explosive astrophysical environments such as novae and X-ray bursts. In this cycle, proton captures by C and N in succession lead to the production of O. Destruction of O occurs by O(β)N and by the O(α,p)F reaction. The slow rate of this reaction can limit energy generation and result in substantial abundances of the O isotope in novae  and X-ray bursts .