The pathogenesis of fungal-related diseases and allergies in the African population: The state of the evidence and knowledge gaps

Lorraine tsitsi Pfavayi, Elopy nimele Sibanda, Francisca Mutapi

Research output: Contribution to journalArticlepeer-review

Abstract

The prevalence of allergic diseases in the African continent has received limited attention with the allergic diseases due to fungal allergens being among the least studied. This lead to the opinion being that the prevalence of allergic disease is low in Africa. Recent reports from different African countries indicate that this is not the case as allergic conditions are common and some; particularly those due to fungal allergens are increasing in prevalence. Thus there is need to understand both the aetiology and pathogenies of these diseases, particularly the neglected fungal allergic diseases. This review addresses currently available knowledge of fungal-induced allergy, disease pathogenesis comparing findings from human vs. experimental mouse studies of fungal allergy. The review discusses the potential role of the gut mycobiome and the extent to which this is relevant to fungal allergy, diagnosis and human health.
Original languageEnglish
Pages (from-to)1-13
JournalInternational archives of allergy and immunology
Early online date18 Feb 2020
DOIs
Publication statusE-pub ahead of print - 18 Feb 2020

Keywords

  • allergy
  • fungi
  • Africa
  • Fungal diseases
  • pathogenesis

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