Abstract
Children with chronic inflammatory diseases, such as juvenile idiopathic arthritis (JIA), suffer from a variety of growth disorders. These range from general growth retardation to local acceleration of growth in the affected limb. These disorders are associated with the increased production of proinflammatory cytokines, which may influence growth through a local effect in the growth plates of long bones and/or systemic effects throughout the whole body. In this article we review these aspects and also discuss the evidence for interaction between the inflammatory cytokine and growth-signalling pathways.
| Original language | English |
|---|---|
| Pages (from-to) | 11-9 |
| Number of pages | 9 |
| Journal | Rheumatology |
| Volume | 45 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2006 |
Keywords
- Arthritis, Juvenile Rheumatoid
- Cytokines
- Gonadal Steroid Hormones
- Growth Disorders
- Growth Hormone
- Growth Plate
- Humans
- Insulin-Like Growth Factor I