Phagocytosis of apoptotic cells is fundamental to animal development, immune function and cellular homeostasis. The phosphatidylserine receptor (Ptdsr) on phagocytes has been implicated in the recognition and engulfment of apoptotic cells and in anti-inflammatory signaling. To determine the biological function of the phosphatidylserine receptor in vivo, we inactivated the Ptdsr gene in the mouse.
- Embryonic Development
- Eye/anatomy & histology
- Mice, Knockout
- Receptors, Cell Surface/genetics
- Receptors, Cell Surface/physiology