The phosphatidylserine receptor has essential functions during embryogenesis but not in apoptotic cell removal

Jens Böse, Achim D Gruber, Laura Helming, Stefanie Schiebe, Ivonne Wegener, Martin Hafner, Marianne Beales, Frank Köntgen, Andreas Lengeling

Research output: Contribution to journalArticlepeer-review

Abstract

Phagocytosis of apoptotic cells is fundamental to animal development, immune function and cellular homeostasis. The phosphatidylserine receptor (Ptdsr) on phagocytes has been implicated in the recognition and engulfment of apoptotic cells and in anti-inflammatory signaling. To determine the biological function of the phosphatidylserine receptor in vivo, we inactivated the Ptdsr gene in the mouse.
Original languageEnglish
Pages (from-to)15
JournalJournal of Biology
Volume3
Issue number4
DOIs
Publication statusPublished - 2004

Keywords

  • Animals
  • Anophthalmos/etiology
  • Apoptosis
  • Cytokines/biosynthesis
  • Embryonic Development
  • Eye/anatomy & histology
  • Eye/embryology
  • Macrophages/immunology
  • Mice
  • Mice, Knockout
  • Organogenesis
  • Phagocytosis
  • Receptors, Cell Surface/genetics
  • Receptors, Cell Surface/physiology

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