The phosphatidylserine receptor has essential functions during embryogenesis but not in apoptotic cell removal

Jens Böse; Achim D Gruber; Laura Helming; Stefanie Schiebe; Ivonne Wegener; Martin Hafner; Marianne Beales; Frank Köntgen; Andreas Lengeling

doi:10.1186/jbiol10

The phosphatidylserine receptor has essential functions during embryogenesis but not in apoptotic cell removal

Jens Böse, Achim D Gruber, Laura Helming, Stefanie Schiebe, Ivonne Wegener, Martin Hafner, Marianne Beales, Frank Köntgen, Andreas Lengeling

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

Phagocytosis of apoptotic cells is fundamental to animal development, immune function and cellular homeostasis. The phosphatidylserine receptor (Ptdsr) on phagocytes has been implicated in the recognition and engulfment of apoptotic cells and in anti-inflammatory signaling. To determine the biological function of the phosphatidylserine receptor in vivo, we inactivated the Ptdsr gene in the mouse.

Original language	English
Pages (from-to)	15
Journal	Journal of Biology
Volume	3
Issue number	4
DOIs	https://doi.org/10.1186/jbiol10
Publication status	Published - 2004

Keywords / Materials (for Non-textual outputs)

Animals
Anophthalmos/etiology
Apoptosis
Cytokines/biosynthesis
Embryonic Development
Eye/anatomy & histology
Eye/embryology
Macrophages/immunology
Mice
Mice, Knockout
Organogenesis
Phagocytosis
Receptors, Cell Surface/genetics
Receptors, Cell Surface/physiology

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10.1186/jbiol10

jbiol_bose_2004
© 2004 Böse et al
Final published version, 2.24 MB

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title = "The phosphatidylserine receptor has essential functions during embryogenesis but not in apoptotic cell removal",

abstract = "Phagocytosis of apoptotic cells is fundamental to animal development, immune function and cellular homeostasis. The phosphatidylserine receptor (Ptdsr) on phagocytes has been implicated in the recognition and engulfment of apoptotic cells and in anti-inflammatory signaling. To determine the biological function of the phosphatidylserine receptor in vivo, we inactivated the Ptdsr gene in the mouse.",

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author = "Jens B{\"o}se and Gruber, \{Achim D\} and Laura Helming and Stefanie Schiebe and Ivonne Wegener and Martin Hafner and Marianne Beales and Frank K{\"o}ntgen and Andreas Lengeling",

year = "2004",

doi = "10.1186/jbiol10",

language = "English",

volume = "3",

pages = "15",

journal = "Journal of Biology",

issn = "1475-4924",

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number = "4",

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T1 - The phosphatidylserine receptor has essential functions during embryogenesis but not in apoptotic cell removal

AU - Böse, Jens

AU - Gruber, Achim D

AU - Helming, Laura

AU - Schiebe, Stefanie

AU - Wegener, Ivonne

AU - Hafner, Martin

AU - Beales, Marianne

AU - Köntgen, Frank

AU - Lengeling, Andreas

PY - 2004

Y1 - 2004

N2 - Phagocytosis of apoptotic cells is fundamental to animal development, immune function and cellular homeostasis. The phosphatidylserine receptor (Ptdsr) on phagocytes has been implicated in the recognition and engulfment of apoptotic cells and in anti-inflammatory signaling. To determine the biological function of the phosphatidylserine receptor in vivo, we inactivated the Ptdsr gene in the mouse.

AB - Phagocytosis of apoptotic cells is fundamental to animal development, immune function and cellular homeostasis. The phosphatidylserine receptor (Ptdsr) on phagocytes has been implicated in the recognition and engulfment of apoptotic cells and in anti-inflammatory signaling. To determine the biological function of the phosphatidylserine receptor in vivo, we inactivated the Ptdsr gene in the mouse.

KW - Animals

KW - Anophthalmos/etiology

KW - Apoptosis

KW - Cytokines/biosynthesis

KW - Embryonic Development

KW - Eye/anatomy & histology

KW - Eye/embryology

KW - Macrophages/immunology

KW - Mice

KW - Mice, Knockout

KW - Organogenesis

KW - Phagocytosis

KW - Receptors, Cell Surface/genetics

KW - Receptors, Cell Surface/physiology

U2 - 10.1186/jbiol10

DO - 10.1186/jbiol10

M3 - Article

C2 - 15345036

SN - 1475-4924

VL - 3

SP - 15

JO - Journal of Biology

JF - Journal of Biology

IS - 4

ER -

The phosphatidylserine receptor has essential functions during embryogenesis but not in apoptotic cell removal

Abstract

Keywords / Materials (for Non-textual outputs)

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