The placenta as a haematopoietic organ

Katrin Ottersbach*, Elaine Dzierzak

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

The recent description of the placenta as a tissue rich in haematopoietic stem and progenitor cells has not only opened up a whole new line of investigation into how haematopoiesis is regulated in this unique mammalian tissue, but has also resulted in the revisiting of long-standing and yet unanswered questions about the significance of having multiple haematopoietic organs during development. Due to its remarkable capacity for haematopoietic stem/progenitor cell expansion, the study of placental haematopoiesis is also of obvious clinical interest. In the following pages, we summarise what is currently known about the haematopoietic regulatory processes in the murine placenta and describe our most recent data demonstrating that the human placenta, like its murine counterpart, is also a source of haematopoietic stem and progenitor cells throughout development.

Original languageEnglish
Pages (from-to)1099-1106
Number of pages8
JournalInternational Journal of Developmental Biology
Volume54
Issue number6-7
DOIs
Publication statusPublished - 2010

Keywords

  • placenta
  • haematapoietic stem cell
  • HSC
  • development
  • MESENCHYMAL PROGENITOR CELLS
  • FETAL LIVER HEMATOPOIESIS
  • STEM-CELLS
  • MOUSE EMBRYO
  • DEFINITIVE HEMATOPOIESIS
  • YOLK-SAC
  • MURINE ALLANTOIS
  • NERVOUS-SYSTEM
  • AGM REGION
  • IN-VIVO

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