The Plasmodium falciparum var gene transcription strategy at the onset of blood stage infection in a human volunteer

Christian W Wang, Cornelus C Hermsen, Robert W Sauerwein, David E Arnot, Thor G Theander, Thomas Lavstsen

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The var genes encode a family of adhesion receptor proteins, Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), which profoundly influence malaria pathogenesis. Only a single var gene is transcribed and one PfEMP1 expressed per P.falciparum parasite. Here we present the in vivo transcript distribution of var genes in a P. falciparum-infected non-immune individual and show that the initial expression of PfEMP1 is based on a strategy that allows all or most variants of PfEMP1s to be expressed by the parasite population at the onset of the blood stage infection.
Original languageEnglish
Pages (from-to)478-480
Number of pages3
JournalInternational Journal For Parasitology
Volume58
Issue number4
Early online date16 Jul 2009
DOIs
Publication statusPublished - 31 Dec 2009

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